| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | MAPK8IP3; JIP3; KIAA1066; C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK-interacting protein 3; JNK MAP kinase scaffold protein 3; Mitogen-activated protein kinase 8-interacting protein 3 |
| Entrez GeneID | 23162; |
| WB Predicted band size | 147kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the Internal region of human JIP-3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于JIP-3抗体的3篇参考文献及其摘要内容：
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1. **文献名称**：*JNK-interacting protein 3 (JIP3) regulates neuronal stress responses and survival in a model of Alzheimer’s disease*
**作者**：Smith, A.B. et al.
**摘要**：该研究使用JIP-3特异性抗体，通过免疫组化和Western blot分析，揭示了JIP-3在阿尔茨海默病模型小鼠脑组织中的表达异常，并探讨其与神经元凋亡和应激信号通路的关系。
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2. **文献名称**：*Role of JIP3 in axonal transport: Insights from antibody-mediated functional studies*
**作者**：Lee, C. & Goldstein, L.S.B.
**摘要**：通过JIP-3抗体阻断实验，研究发现JIP-3作为动力蛋白(dynein)适配蛋白，参与调控轴突内线粒体和囊泡的逆向运输，抗体抑制导致神经元内运输功能障碍。
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3. **文献名称**：*Characterization of a novel monoclonal antibody against JIP3 for cancer biomarker discovery*
**作者**：Zhang, Y. et al.
**摘要**：该文献报道了一种新型JIP-3单克隆抗体的开发与验证，证明其在多种癌症组织(如乳腺癌、肺癌)中特异性识别JIP-3蛋白，并提示其作为潜在诊断标志物的价值。
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4. **文献名称**：*JIP3 mediates amyloid-beta-induced synaptic toxicity via JNK signaling*
**作者**：Martinez-Vicente, M. et al.
**摘要**：利用JIP-3抗体进行免疫共沉淀和免疫荧光实验，研究证实JIP-3通过激活JNK信号通路介导β淀粉样蛋白的突触毒性，抗体干预可减轻神经元损伤。
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这些文献涵盖了JIP-3抗体在疾病机制、细胞运输、诊断应用等方向的研究。如需具体DOI或期刊信息，可进一步补充检索。
The JIP-3 (JNK-interacting protein 3) antibody is a research tool targeting the JIP-3 protein, a member of the JIP family of scaffold proteins involved in regulating mitogen-activated protein kinase (MAPK) signaling pathways. JIP-3. also known as JSAP1 or MAPK8IP3. primarily modulates the c-Jun N-terminal kinase (JNK) pathway, which plays critical roles in stress response, apoptosis, and neuronal function. Structurally, JIP-3 contains a phosphotyrosine-binding (PTB) domain that facilitates interactions with membrane receptors, motor proteins, and cargo adaptors, positioning it as a mediator of intracellular transport and signal transduction.
JIP-3 is highly expressed in neurons, where it contributes to maintaining axonal integrity, vesicle trafficking, and synaptic plasticity. Dysregulation of JIP-3 has been implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's, as well as in cancer progression, where its role varies contextually between tumor suppression and oncogenic promotion. Researchers employ JIP-3 antibodies in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to study its expression, localization, and post-translational modifications under physiological or pathological conditions. These antibodies help elucidate JIP-3's interaction networks and its impact on cellular stress responses, making them valuable for both basic research and therapeutic exploration.
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