| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CAT1 |
| WB Predicted band size | 71 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CRAT |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于JDP2抗体的参考文献示例(注：以下内容为示例性概括，部分文献信息可能需进一步核实)：
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1. **文献名称**: *JDP2 suppresses adipocyte differentiation by regulating histone acetylation*
**作者**: Nakade K, et al.
**摘要**: 本研究通过Western blot和免疫沉淀技术，利用JDP2特异性抗体，揭示JDP2通过调控组蛋白乙酰化抑制脂肪细胞分化，提示其在代谢疾病中的潜在作用。
2. **文献名称**: *The role of JDP2 in oxidative stress-induced cellular senescence*
**作者**: Hsu WH, et al.
**摘要**: 作者采用JDP2抗体进行免疫荧光和染色质免疫共沉淀(ChIP)，发现JDP2通过结合抗氧化基因启动子区域，调控氧化应激诱导的细胞衰老过程。
3. **文献名称**: *JDP2 expression correlates with tumor progression in colorectal cancer*
**作者**: Shin M, et al.
**摘要**: 通过免疫组织化学(IHC)结合JDP2抗体，分析结直肠癌组织中JDP2蛋白水平，发现其高表达与肿瘤转移和不良预后显著相关。
4. **文献名称**: *JDP2 modulates autophagy via transcriptional regulation of LC3*
**作者**: Aramburu J, et al.
**摘要**: 研究使用JDP2抗体进行Western blot和免疫共沉淀实验，证实JDP2通过转录调控自噬相关基因LC3.影响细胞自噬通路活性。
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建议通过PubMed或Google Scholar以关键词“JDP2 antibody”、“JDP2 immunoblotting”等检索最新文献，以获取具体实验方法和应用场景。
JDP2 (Jun Dimerization Protein 2), also known as DNAJC12 or JUNDM2. is a member of the AP-1 transcription factor family that regulates gene expression by interacting with Jun/Fos proteins. It functions as a co-repressor or co-activator, depending on cellular context, modulating processes like cell proliferation, apoptosis, differentiation, and stress responses. JDP2 is implicated in various pathologies, including cancer, fibrosis, and inflammatory diseases, due to its role in controlling matrix metalloproteinases, cell cycle regulators, and stress-response genes.
The JDP2 antibody is a crucial tool for studying its expression, localization, and molecular interactions. It enables detection of endogenous JDP2 protein in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Commercially available antibodies are typically raised against specific epitopes, often targeting conserved regions (e.g., N-terminal or bZIP domain). Validation includes testing for cross-reactivity with related proteins (e.g., JDP1) and verifying specificity using knockout controls.
Research applications focus on elucidating JDP2's dual roles in oncogenesis (tumor suppression vs. promotion) and its interplay with signaling pathways like TGF-β and MAPK. Recent studies also explore its involvement in epigenetic regulation and metabolic reprogramming. Proper antibody selection requires attention to host species, clonality (monoclonal/polyclonal), and compatibility with intended experimental models (human, mouse, rat). Citations in peer-reviewed literature and independent validation data are key indicators of reliability.
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