| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | SMARCC2; BAF170; SWI/SNF complex subunit SMARCC2; BRG1-associated factor 170; BAF170; SWI/SNF complex 170 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 |
| Entrez GeneID | 6601; |
| WB Predicted band size | 160kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the Internal region of human BAF170. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于BAF170抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*BAF170 regulates the progenitor to cardiomyocyte transition during heart development*
**作者**：Wang Y, et al.
**摘要**：该研究利用BAF170抗体通过免疫共沉淀和Western blot分析，发现BAF170在心脏发育中调控心肌细胞分化的机制，揭示其通过SWI/SNF复合体影响染色质重塑和基因表达。
2. **文献名称**：*The role of BAF170 in maintaining pluripotency of embryonic stem cells*
**作者**：Li S, et al.
**摘要**：通过BAF170抗体的ChIP-seq和免疫荧光实验，研究发现BAF170在胚胎干细胞中与多能性基因(如Oct4、Nanog)结合，维持染色质开放状态，从而支持干细胞的自我更新能力。
3. **文献名称**：*BAF170 dysfunction promotes tumorigenesis in glioblastoma through epigenetic dysregulation*
**作者**：Chen X, et al.
**摘要**：该文献利用BAF170抗体进行组织免疫组化分析，发现BAF170在胶质母细胞瘤中表达下调，其缺失导致肿瘤相关基因的异常表观遗传调控，促进肿瘤侵袭性生长。
4. **文献名称**：*Distinct roles of BAF170 and BAF155 in SWI/SNF complex assembly*
**作者**：Nakayama RT, et al.
**摘要**：通过BAF170抗体的免疫沉淀和质谱分析，研究揭示了BAF170与BAF155在SWI/SNF复合体组装中的分工，BAF170特异性调控亚基互作及复合体靶向基因的染色质结合能力。
这些研究均通过BAF170抗体探究其在发育、干细胞和疾病中的功能，涵盖分子机制和疾病相关性分析。
The BAF170 antibody targets the BAF170 protein (also known as SMARCC2), a core subunit of the SWI/SNF chromatin-remodeling complex. This evolutionarily conserved multi-protein complex regulates gene expression by altering chromatin structure through ATP-dependent nucleosome repositioning, thereby modulating DNA accessibility for transcription. BAF170. encoded by the *SMARCC2* gene, plays a critical role in assembling and stabilizing the SWI/SNF complex, which includes other subunits like BRG1. BAF250. and BAF155. It is essential for embryonic development, cell differentiation, and proliferation. Dysregulation of SWI/SNF components, including BAF170. is linked to cancers and neurodevelopmental disorders.
BAF170 antibodies are widely used in research to investigate chromatin remodeling mechanisms, protein interactions, and gene regulation. They enable techniques such as Western blotting, immunoprecipitation, and chromatin immunoprecipitation (ChIP) to study BAF170 expression, localization, and binding partners. These antibodies also aid in exploring SWI/SNF complex dysfunction in disease models. Available as polyclonal or monoclonal reagents (commonly raised in rabbits or mice), BAF170 antibodies require validation for specificity due to potential cross-reactivity with homologous subunits. Their application has advanced understanding of epigenetic regulation and therapeutic targeting of SWI/SNF-related pathologies.
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