| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | APOE; Apolipoprotein E; Apo-E |
| Entrez GeneID | 348; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human ApoE. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于ApoE抗体的3篇文献示例(文献信息为模拟虚构，仅供示例参考)：
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1. **文献名称**: *"ApoE-Specific Monoclonal Antibodies for Detection of Alzheimer's Disease Pathology"*
**作者**: Smith J, et al.
**摘要**: 本研究开发了针对ApoE不同亚型(ApoE2/E3/E4)的高特异性单克隆抗体，用于阿尔茨海默病患者的脑组织免疫组化分析。抗体成功区分了不同ApoE亚型在淀粉样斑块中的分布，为病理分型提供了新工具。
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2. **文献名称**: *"ApoE Antibody-Based ELISA Assay for Cardiovascular Risk Assessment"*
**作者**: Lee H, et al.
**摘要**: 研究利用多克隆ApoE抗体建立了一种高灵敏ELISA检测方法，用于定量人血清中ApoE浓度。该方法在评估动脉粥样硬化患者的脂代谢异常中显示出临床相关性，灵敏度达0.1 ng/mL。
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3. **文献名称**: *"Epitope Mapping of ApoE Antibodies and Their Cross-Reactivity in Neurodegenerative Disorders"*
**作者**: Garcia R, et al.
**摘要**: 通过表位定位技术分析了商品化ApoE抗体的结合特性，发现部分抗体与tau蛋白存在交叉反应。研究强调抗体选择对神经退行性疾病研究结果可靠性的影响，并推荐了特异性更优的抗体克隆。
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(注：以上文献为示例，实际引用需通过PubMed、Google Scholar等平台检索真实文献。建议使用关键词如“ApoE antibody application”或“ApoE immunoassay”进行查询。)
Apolipoprotein E (ApoE) is a lipid-binding protein critical for cholesterol transport and lipid metabolism in the brain and peripheral tissues. It exists in three major isoforms (ApoE2. ApoE3. ApoE4) encoded by the *APOE* gene, with ApoE4 being a well-established genetic risk factor for late-onset Alzheimer’s disease (AD). ApoE antibodies are essential tools in biomedical research and diagnostics, designed to detect, quantify, or modulate ApoE isoforms and their functions.
In AD research, ApoE antibodies help elucidate the protein’s role in amyloid-beta (Aβ) aggregation, clearance, and neuroinflammation. ApoE4 is associated with impaired Aβ clearance and increased neurotoxicity, making isoform-specific antibodies valuable for studying disease mechanisms. These antibodies are also used in immunohistochemistry, ELISA, and Western blotting to assess ApoE expression levels in tissues or biofluids, aiding in biomarker discovery.
Therapeutic ApoE antibodies are under exploration to mitigate AD pathology. Some aim to block ApoE-Aβ interactions, while others seek to enhance ApoE-mediated lipid transport or modulate neuroinflammatory responses. Challenges include ensuring antibody specificity to target isoforms and avoiding off-target effects in the brain.
Beyond AD, ApoE antibodies contribute to cardiovascular research, as ApoE influences lipid metabolism and atherosclerosis. Their dual role in neurodegenerative and metabolic diseases underscores their broad relevance in understanding and treating complex disorders linked to ApoE dysfunction.
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