| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | SLC25A6; ANT3; CDABP0051; ADP/ATP translocase 3; ADP; ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6 |
| Entrez GeneID | 293; |
| WB Predicted band size | 32kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human ANT3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于ANT3抗体的示例参考文献(注：部分信息可能为模拟或简化，建议通过学术数据库验证)：
1. **文献名称**: "Differential roles of ANT isoforms in mitochondrial membrane permeabilization"
**作者**: Marzo, I., et al.
**摘要**: 研究通过Western blot和免疫荧光分析ANT3在HeLa细胞中的定位，发现其在线粒体通透性转换孔形成中的调控作用，区别于ANT1/ANT2.
2. **文献名称**: "ANT3 deficiency confers resistance to apoptosis via modulating Bcl-2 family proteins"
**作者**: Brenner, C., et al.
**摘要**: 利用ANT3抗体进行基因敲除实验，发现ANT3缺失导致细胞凋亡受阻，可能与Bax/Bak活化抑制相关。
3. **文献名称**: "Tissue-specific expression and metabolic role of ANT3 in murine models"
**作者**: Kokoszka, J.E., et al.
**摘要**: 通过免疫组化分析ANT3抗体标记的小鼠组织，揭示其在心脏和骨骼肌中高表达，并参与ATP/ADP转运调控。
4. **文献名称**: "ANT3 overexpression correlates with chemoresistance in colorectal cancer"
**作者**: Garcia-Bermudez, J., et al.
**摘要**: 使用ANT3抗体检测临床样本，发现其在化疗耐药患者的肿瘤组织中表达显著上调，提示其作为预后标志物的潜力。
**备注**：以上文献为示例性质，实际引用需通过PubMed、Google Scholar等平台以“Adenine Nucleotide Translocator 3”或“SLC25A6”为关键词检索确认。若涉及抗凝血酶III(Antithrombin III)，建议核对缩写准确性。
The ANT3 antibody targets Adenine Nucleotide Translocator 3 (ANT3), a mitochondrial inner membrane protein encoded by the *SLC25A6* gene in humans. ANT3 facilitates the exchange of ADP and ATP across the mitochondrial membrane, a critical process for cellular energy metabolism. As a member of the solute carrier 25 (SLC25) family, ANT3 shares structural homology with other ANT isoforms (ANT1. ANT2. ANT4) but exhibits distinct tissue expression patterns, with prominence in immune cells, skeletal muscle, and the liver.
ANT3 has been implicated in mitochondrial-mediated apoptosis, as its conformational changes can trigger cytochrome c release, activating caspase cascades. Dysregulation of ANT3 is linked to pathologies such as cancer, neurodegenerative disorders, and immune dysfunctions. For instance, altered ANT3 expression has been observed in certain cancers, suggesting a role in tumor cell survival or chemoresistance.
The ANT3 antibody is widely used in research to investigate mitochondrial function, apoptosis, and metabolic diseases. It aids in detecting ANT3 via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore its potential as a biomarker or therapeutic target, particularly in diseases involving mitochondrial dysfunction. Despite its importance, overlapping functions with other ANT isoforms necessitate careful experimental validation to ensure specificity in studies.
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