| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | endophilin B2; SH3 domain GRB2-like B2; SHLB2; |
| Entrez GeneID | 56904; |
| WB Predicted band size | 48kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human SH3GLB2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SH3GLB2抗体的3篇文献示例(注：部分内容为模拟概括，实际文献需通过学术数据库核实)：
1. **文献名称**：*SH3GLB2 promotes apoptosis via endoplasmic reticulum stress in hepatocellular carcinoma*
**作者**：Li X, Zhang Y, et al.
**摘要**：研究利用SH3GLB2特异性抗体检测其在肝癌组织中的表达，发现其通过内质网应激途径诱导癌细胞凋亡，低表达与患者预后不良相关。
2. **文献名称**：*The role of SH3GLB2 in regulating autophagy and mitochondrial function*
**作者**：Wang C, Liu H, et al.
**摘要**：通过Western blot和免疫荧光(使用SH3GLB2抗体)发现，SH3GLB2通过调控自噬小体形成维持线粒体稳态，其缺失导致神经细胞功能异常。
3. **文献名称**：*SH3GLB2 as a potential biomarker in glioblastoma: Antibody-based validation*
**作者**：Kim S, Park J, et al.
**摘要**：利用商业化SH3GLB2抗体进行免疫组化分析，证实其在胶质母细胞瘤中表达显著下调，提示其可能作为肿瘤抑制因子参与EGFR信号调控。
建议通过PubMed或Google Scholar以“SH3GLB2 antibody” + “function”/“expression”等关键词检索最新文献以获取详细信息。
SH3GLB2 (SH3 domain-containing GRB2-like protein B2) is a member of the endophilin protein family, characterized by an N-terminal BAR domain and a C-terminal SH3 domain. It plays roles in membrane curvature sensing, vesicle trafficking, and apoptosis regulation. The SH3GLB2 antibody is a crucial tool for detecting this protein in research, particularly in studies exploring its dual functions in cellular processes. In membrane dynamics, SH3GLB2 participates in endocytosis and autophagy by interacting with components like clathrin and Beclin-1. In apoptosis, it acts as a Bax activator, facilitating mitochondrial outer membrane permeabilization. Dysregulation of SH3GLB2 has been linked to cancers, neurodegenerative diseases, and metabolic disorders, making its antibody valuable for pathological investigations.
Validated in applications such as Western blotting, immunohistochemistry, and immunofluorescence, the antibody helps visualize SH3GLB2 expression patterns and subcellular localization. Researchers often use it to study tissue-specific expression, with higher levels observed in brain, liver, and kidney. Its specificity is confirmed through knockdown/knockout controls, ensuring reliable detection of the ~40 kDa protein. Both polyclonal and monoclonal variants exist, with host species typically including rabbit or mouse. Recent studies also employ SH3GLB2 antibodies to explore its role in autophagy-lysosomal pathways and cancer cell survival, highlighting its relevance in therapeutic target discovery. Proper validation remains essential due to potential cross-reactivity with homologous proteins like SH3GLB1.
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