| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SH2 domain-containing protein 5; SH2D5; |
| Entrez GeneID | 400745; |
| WB Predicted band size | 35kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human SH2D5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SH2D5抗体的假设性参考文献示例(实际文献可能需要通过学术数据库验证)：
1. **"Characterization of SH2D5-Specific Antibodies for Neuronal Signaling Studies"**
- **作者**: Tanaka K, et al.
- **摘要**: 研究报道了针对SH2D5蛋白的多克隆抗体的开发与验证，通过免疫印迹和免疫组化证实其在神经元组织中的特异性表达，并探讨SH2D5在突触可塑性中的潜在作用。
2. **"SH2D5 Antibody Reveals Its Role in Cancer Cell Migration"**
- **作者**: Smith L, et al.
- **摘要**: 利用单克隆SH2D5抗体研究其在多种癌细胞系中的表达模式，发现SH2D5通过调节细胞骨架重组促进肿瘤侵袭，为癌症治疗提供潜在靶点。
3. **"Structural Analysis of SH2D5 Using Epitope-Specific Antibodies"**
- **作者**: Chen R, et al.
- **摘要**: 通过筛选SH2D5抗原表位特异性抗体，解析其SH2结构域与磷酸化酪氨酸肽段的结合机制，揭示其在信号转导中的分子互作网络。
4. **"SH2D5 Antibody-Based Detection in Neurodegenerative Disorders"**
- **作者**: Müller J, et al.
- **摘要**: 开发高灵敏度SH2D5抗体用于脑脊液检测，发现其在阿尔茨海默病患者中表达异常，提示SH2D5可能与tau蛋白病理过程相关。
**注意**：以上内容为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词(如"SH2D5 antibody"或"SH2D5 function")。部分研究可能聚焦于SH2D5基因功能而非抗体开发，建议结合具体需求筛选。
The SH2D5 antibody targets the SH2 domain-containing protein 5 (SH2D5), a member of the Src homology 2 (SH2) domain protein family. SH2 domains mediate protein-protein interactions by binding phosphorylated tyrosine residues, playing critical roles in signal transduction pathways. While SH2D5's precise biological function remains under investigation, it is implicated in regulating cellular processes such as growth, differentiation, and apoptosis. Its structure includes a central SH2 domain, which likely facilitates interactions with tyrosine-phosphorylated signaling molecules, and a conserved N-terminal region that may contribute to subcellular localization or partner binding.
SH2D5 antibodies are primarily used as research tools to study the protein's expression, localization, and interactions in various tissues and disease models. Studies suggest SH2D5 is expressed in neuronal tissues, with potential roles in brain development and synaptic plasticity. Aberrant SH2D5 expression has been observed in certain cancers, including gliomas and breast cancer, hinting at possible oncogenic or tumor-suppressive functions depending on context. However, mechanistic insights remain limited, and its signaling partners are not fully characterized.
Current research employs SH2D5 antibodies in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore its involvement in pathological conditions. The antibody's development aids in clarifying SH2D5's contribution to tyrosine kinase-driven pathways and its potential as a therapeutic target. Further validation of its specificity and functional studies are needed to establish its clinical relevance.
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