Rabbit Polyclonal SH3TC1 Antibody

The SH3TC1 antibody is a research tool used to detect the SH3TC1 protein, encoded by the *SH3TC1* gene, which plays a role in peripheral nerve myelination. SH3TC1 contains an SH3 domain and TPR motifs, facilitating protein-protein interactions critical for Schwann cell function. Mutations in *SH3TC1* are linked to Charcot-Marie-Tooth disease (CMT), a hereditary neuropathy characterized by motor and sensory deficits. Specifically, SH3TC1 interacts with SH3TC2. forming a complex involved in intracellular trafficking and membrane dynamics in myelinating glia. Antibodies targeting SH3TC1 enable researchers to study its expression, localization, and interactions in nerve tissues, aiding investigations into CMT pathogenesis. These antibodies are typically validated in applications like Western blotting, immunohistochemistry, or immunofluorescence. Studying SH3TC1 also sheds light on broader mechanisms of myelination and axon-glial communication. However, SH3TC1-related CMT cases are rare compared to other genetic subtypes, emphasizing the need for precise molecular tools to explore its specific contributions to neuropathy. Research using SH3TC1 antibodies continues to clarify its role in cellular pathways and potential therapeutic targets.