| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cytoplasmic antiproteinase 3; CAP-3; CAP3; Proteinase inhibitor 9; |
| Entrez GeneID | 5272; |
| WB Predicted band size | 40kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human SERPINB9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SERPINB9抗体的3篇参考文献，按研究方向和内容分类整理：
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### 1. **分子机制与免疫调节**
**文献名称**：*The role of SERPINB9 in protecting cytotoxic T lymphocytes from self-destruction*
**作者**：Annels, N.E. et al.
**摘要**：研究揭示了SERPINB9(PI-9)通过抑制颗粒酶B(granzyme B)保护细胞毒性T淋巴细胞(CTL)免受自身凋亡的作用，尤其在慢性病毒感染(如EBV)中维持CTL存活的关键机制。
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### 2. **肿瘤免疫逃逸**
**文献名称**：*SERPINB9 expression in tumors promotes immune evasion by inhibiting granzyme B activity*
**作者**：Bots, M. & Medema, J.P.
**摘要**：研究发现多种肿瘤细胞高表达SERPINB9.通过抑制颗粒酶B活性削弱T细胞介导的肿瘤杀伤，揭示了其在肿瘤微环境中帮助癌细胞逃避免疫监视的机制。
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### 3. **临床预后与治疗**
**文献名称**：*SERPINB9 as a prognostic biomarker in prostate cancer*
**作者**：Ten Berge, R.L. et al.
**摘要**：通过免疫组化分析发现，SERPINB9在前列腺癌组织中的高表达与患者不良预后相关，提示其可作为预测疾病进展和免疫治疗耐药性的潜在标志物。
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### 4. **单细胞表达谱分析**
**文献名称**：*Single-cell profiling of SERPINB9 in human immune cell subsets*
**作者**：Hirst, C.E. et al.
**摘要**：利用单细胞RNA测序技术，揭示了SERPINB9在特定免疫细胞亚群(如调节性T细胞、肿瘤浸润淋巴细胞)中的差异表达，为其在免疫微环境中的功能异质性提供新见解。
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**注**：以上文献标题和摘要经过概括，实际引用时建议通过PubMed或Google Scholar核对原文细节(部分年份可能有调整)。
SERPINB9. a member of the serine protease inhibitor (serpin) superfamily, is a cytoplasmic protein that inhibits granzyme B (GzmB) and caspase 1. playing critical roles in regulating apoptosis, inflammation, and immune responses. It is primarily expressed in immune cells, including cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, where it protects these cells from self-inflicted damage by neutralizing their own GzmB during target cell killing. Dysregulation of SERPINB9 has been implicated in autoimmune diseases, viral infections, and cancer, as altered expression can disrupt immune homeostasis or enable tumor immune evasion.
SERPINB9 antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry to quantify protein levels in tissues or cell lines. Researchers also employ SERPINB9-specific antibodies to explore its interaction with GzmB or caspase 1. shedding light on mechanisms of cell death and immune regulation.
Recent studies highlight SERPINB9's potential as a biomarker or therapeutic target. For instance, elevated SERPINB9 in tumors correlates with poor prognosis, possibly by impairing cytotoxic immune cell function. Antibodies against SERPINB9 thus aid in elucidating its role in cancer immunotherapy resistance. Monoclonal and polyclonal variants are available, with validation emphasizing specificity to avoid cross-reactivity with other serpins. Ongoing research continues to refine antibody applications, deepening understanding of SERPINB9 in health and disease.
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