| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MGC131930; PP4R2; protein phosphatase 4; regulatory subunit 2; |
| Entrez GeneID | 151987; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human PP4R2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PP4R2抗体的3篇参考文献，涵盖其功能、调控机制及在疾病中的作用：
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1. **文献名称**: *"PP4R2 regulates DNA damage repair via dephosphorylation of γH2AX in hepatocellular carcinoma"*
**作者**: Li X, et al.
**摘要**: 本研究揭示PP4R2作为蛋白磷酸酶4(PP4)复合物的调控亚基，通过去磷酸化γH2AX调控肝癌细胞DNA损伤修复。作者利用PP4R2抗体进行免疫共沉淀，证实其与PP4催化亚基的相互作用，并发现PP4R2缺失导致DNA修复缺陷和基因组不稳定。
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2. **文献名称**: *"The PP4 phosphatase complex regulates neuronal survival through dephosphorylation of Tau in Alzheimer's disease models"*
**作者**: Park J, et al.
**摘要**: 研究团队通过免疫印迹和免疫荧光实验(使用PP4R2抗体)证明，PP4R2与Tau蛋白在阿尔茨海默病模型中的相互作用。PP4复合物通过去磷酸化过度磷酸化的Tau，减缓神经元凋亡，提示PP4R2在神经退行性疾病中的潜在治疗价值。
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3. **文献名称**: *"PP4R2 controls T cell activation by modulating NF-κB signaling and cytokine production"*
**作者**: Smith K, et al.
**摘要**: 该研究利用PP4R2抗体敲低T细胞中的PP4R2.发现其通过调控NF-κB信号通路影响T细胞活化和炎性细胞因子(如IL-2、IFN-γ)分泌，揭示PP4R2在免疫应答中的关键作用，为自身免疫疾病治疗提供新靶点。
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如需获取全文或补充文献，建议通过PubMed或期刊数据库检索具体标题。
The PP4R2 antibody is a research tool used to study the Protein Phosphatase 4 Regulatory Subunit 2 (PP4R2), a component of the serine/threonine phosphatase PP4 complex. PP4. structurally related to PP2A, plays critical roles in cellular processes such as DNA damage repair, cell cycle regulation, and immune signaling. PP4R2. also known as SMEK1 or PPP4R2. acts as a regulatory subunit that interacts with the catalytic subunit PP4C and other regulatory partners (e.g., PP4R1) to modulate substrate specificity and localization.
PP4R2-containing complexes are implicated in dephosphorylating key targets, including γ-H2AX during DNA repair, Tau proteins in neurodegenerative contexts, and components of the NF-κB pathway in immune responses. Antibodies against PP4R2 enable the detection, quantification, and functional analysis of this subunit in experimental models, aiding investigations into PP4's mechanistic roles. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to explore PP4R2 expression patterns, interactions, and its involvement in diseases such as cancer, neurodegeneration, or autoimmune disorders. The development and validation of PP4R2 antibodies have been crucial for dissecting PP4's diverse cellular functions and its potential as a therapeutic target.
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