Rabbit Polyclonal RAB40B Antibody

The RAB40B antibody is a tool used to detect and study the RAB40B protein, a member of the RAB GTPase family involved in intracellular membrane trafficking and vesicular transport. RAB40B, encoded by the *RAB40B* gene, regulates cargo sorting, organelle dynamics, and secretory pathways by cycling between active GTP-bound and inactive GDP-bound states. Unlike other RAB proteins, RAB40B contains a SOCS box domain, suggesting roles in protein degradation via E3 ubiquitin ligase complexes. It is implicated in processes like cytokinesis, exosome release, and neuronal signaling. Dysregulation of RAB40B has been linked to cancers, neurological disorders, and metabolic diseases. The antibody enables researchers to investigate RAB40B's expression, localization, and interactions in cells or tissues using techniques like Western blotting, immunofluorescence, or immunohistochemistry. Commercial RAB40B antibodies are typically raised in rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions). Validation includes testing for specificity using knockout controls or siRNA knockdown. Research using this antibody contributes to understanding RAB40B's role in cellular homeostasis, disease mechanisms, and potential therapeutic targets.