| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ras-related protein Rab-31; Ras-related protein Rab-22B; |
| Entrez GeneID | 11031; |
| WB Predicted band size | 21kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human RAB31. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RAB31抗体的3篇参考文献概览(基于已有研究方向的合理推测)：
1. **文献名称**：RAB31 drives pro-metastatic switch through EGFR signaling in breast cancer
**作者**：Wang X, et al.
**摘要**：研究利用RAB31抗体进行免疫印迹和免疫荧光实验，发现RAB31通过调控EGFR内吞和下游MAPK信号通路促进乳腺癌转移，高表达RAB31与患者不良预后相关。
2. **文献名称**：RAB31 interacts with GABARAP and modulates autophagosome-lysosome fusion
**作者**：Chen Y, et al.
**摘要**：通过免疫共沉淀(使用RAB31抗体)和细胞成像技术，揭示了RAB31通过与自噬相关蛋白GABARAP相互作用，影响自噬体-溶酶体融合过程，为神经退行性疾病机制提供新线索。
3. **文献名称**：RAB31 as a potential biomarker in glioblastoma: Immunohistochemical analysis
**作者**：Li H, et al.
**摘要**：利用RAB31特异性抗体对胶质母细胞瘤组织进行免疫组化分析，发现RAB31表达水平与肿瘤分级和患者生存期显著相关，提示其作为预后标志物的潜力。
*注：以上为模拟文献案例，实际引用需核实真实出版物信息。建议通过PubMed或Google Scholar以“RAB31 antibody”或“RAB31 function”为关键词检索最新论文。*
**Background of RAB31 Antibody**
RAB31. a member of the RAS oncogene family, is a small GTPase involved in regulating intracellular vesicular trafficking and signal transduction. It plays a critical role in membrane trafficking pathways, particularly in endosomal sorting and receptor recycling, impacting processes like cell proliferation, differentiation, and apoptosis. Dysregulation of RAB31 has been linked to various cancers, including breast, glioblastoma, and pancreatic cancer, where its overexpression often correlates with tumor progression, metastasis, and drug resistance.
RAB31 antibodies are essential tools for studying its expression, localization, and function. These antibodies are typically developed against specific epitopes of the RAB31 protein and validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. High-quality RAB31 antibodies enable researchers to investigate its interaction with effector molecules (e.g., kinases, phosphatases) and its role in trafficking key receptors (e.g., EGFR, integrins).
Additionally, RAB31 antibodies aid in exploring its involvement in neurological disorders, such as Alzheimer’s disease, where aberrant vesicle transport contributes to pathological protein accumulation. Validation of antibody specificity, often through knockout cell lines or siRNA-mediated silencing, is crucial to ensure reliable experimental outcomes. As research advances, RAB31 antibodies remain pivotal in unraveling its therapeutic potential as a biomarker or drug target in precision medicine.
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