关键信息
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基因名
LCE4A
- 应用
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别名
LCE4A; LEP8; SPRL4ALate cornified envelope protein 4A; Late envelope protein 8; Small proline-rich-like epidermal differentiation complex protein 4A
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5TA78
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表达区间
1-99aa
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氨基酸序列
MSCQQNQQQCQPPPKCPIPKYPPKCPSKCASSCPPPISSCCGSSSGGCGCCSSEGGGCCLSHHRHHRSHCHRPKSSNCYGSGSGQQSGGSGCCSGGGCC
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分子量
10.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
LCE4A (Late Cornified Envelope 4A) is a member of the LCE gene family, which plays a crucial role in the process of keratinization and skin barrier function. This family is predominantly expressed in the epithelium, particularly in the skin, where it contributes to the formation of the stratum corneum, the outermost layer that protects against environmental insults. Recent studies have highlighted the involvement of LCE4A in various dermatological conditions, such as psoriasis and atopic dermatitis, suggesting its potential as a biomarker for inflammation and skin barrier dysfunction. The recombinant protein form of LCE4A serves as a valuable tool in research aimed at elucidating its functional properties. By investigating its structure and biological activities, researchers can better understand its role in skin-related diseases and explore its therapeutic potential. Additionally, the generation of LCE4A recombinant protein enables the development of assays to assess its interaction with cellular pathways, immune responses, and contribution to the skin's physiological state. Given the rising incidence of skin disorders worldwide, LCE4A and its recombinant forms present exciting prospects for advancing dermatological research and potential novel treatment strategies.
