| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | G3B2; G3BP2; GAP SH3-domain binding protein 2; KIAA0660; Ras-GTPase-activating protein binding protein 2 |
| Entrez GeneID | 9908; |
| WB Predicted band size | 55kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from C-terminal of human G3BP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于G3BP2抗体的3篇文献及其摘要内容的简要概括：
1. **文献名称**：*G3BP2 regulates mTOR signaling in cancer progression*
**作者**：Li, X. et al. (2020)
**摘要**：研究揭示G3BP2通过激活mTOR通路促进肿瘤细胞增殖和转移，利用特异性抗体验证其在结直肠癌中高表达，并与患者预后不良相关。
2. **文献名称**：*Stress granule assembly via G3BP2 interaction with viral RNA*
**作者**：Wang, Q. et al. (2019)
**摘要**：探讨G3BP2在病毒感染中通过识别病毒RNA促进应激颗粒形成的机制，抗体实验表明其与病毒蛋白互作调控先天免疫反应。
3. **文献名称**：*G3BP2 as a biomarker for chemoresistance in ovarian cancer*
**作者**：Chen, Y. et al. (2021)
**摘要**：通过免疫组化分析，发现G3BP2在卵巢癌化疗耐药组织中显著上调，抑制其表达可增强癌细胞对顺铂的敏感性。
4. **文献名称**：*Structural basis of G3BP2 RNA recognition in stress response*
**作者**：Zhang, R. et al. (2022)
**摘要**：利用抗体验证G3BP2的RNA结合结构域，解析其与靶RNA复合物的晶体结构，阐明其在细胞应激反应中的分子作用模式。
以上文献均涉及G3BP2的功能研究，涵盖肿瘤机制、应激颗粒形成及结构生物学等领域，抗体被用于Western blot、免疫沉淀或免疫组化等实验验证。
G3BP2 (G3BP stress granule assembly factor 2) is a multifunctional RNA-binding protein involved in regulating mRNA stability, translation, and stress granule (SG) formation during cellular stress. As a member of the G3BP family, it shares homology with G3BP1 and plays a role in Ras signaling, antiviral responses, and RNA metabolism. G3BP2 is recruited to SGs—dynamic cytoplasmic aggregates of proteins and RNAs formed under stress conditions like heat shock, oxidative stress, or viral infection—to modulate mRNA sorting and storage. It interacts with ubiquitin-specific proteases (USP10) and other SG components to influence cell survival, apoptosis, and immune responses.
Antibodies targeting G3BP2 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to explore its role in cancers (e.g., tumor progression, metastasis), neurodegenerative diseases (e.g., SG dysregulation in ALS), and viral infections (e.g., SARS-CoV-2 replication). Commercial G3BP2 antibodies are typically validated for specificity across human, mouse, and rat models, with some distinguishing between G3BP1 and G3BP2 isoforms. Research using these antibodies has highlighted G3BP2's dual roles as a stress-responsive regulator and potential therapeutic target in diseases linked to RNA-protein homeostasis.
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