Rabbit Polyclonal RANBP6 Antibody

The RANBP6 antibody is a tool used to study the RAN Binding Protein 6. a member of the RAN GTPase-associated protein family. RANBP6 is implicated in nucleocytoplasmic transport, mitotic regulation, and cellular signaling. It interacts with RAN, a small GTPase critical for shuttling proteins and RNA between the nucleus and cytoplasm. RANBP6 is thought to act as a transport factor, facilitating cargo binding to nuclear transport receptors like importins and exportins. Dysregulation of RANBP6 has been linked to diseases, including cancer, where altered expression may affect cell cycle progression or genomic stability. Studies suggest its potential role as a tumor suppressor or oncogene, depending on cellular context. The RANBP6 antibody enables detection and localization of the protein via techniques such as Western blotting, immunofluorescence, and immunohistochemistry. It is crucial for investigating RANBP6's expression patterns, post-translational modifications, and interactions in normal physiology and disease models. Recent research also explores its involvement in viral infection responses and specific signaling pathways (e.g., TGF-β). Commercial antibodies are typically raised in rabbits or mice, with validation emphasizing specificity to avoid cross-reactivity with other RAN-binding proteins. This tool advances understanding of RANBP6's multifaceted roles in cellular homeostasis and pathology.