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Rabbit Polyclonal RANBP6 Antibody

  • 中文名： RANBP6抗体
  • 别    名： RAN binding 6; RNBP6;
货号: IPDX42549
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRAN binding 6; RNBP6;
Entrez GeneID26953;
WB Predicted band size125kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from internal of human RANBP6.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇与RANBP6抗体相关的文献概览(注：RANBP6研究相对较少，部分文献可能非直接抗体研究，但涉及相关功能)：

1. **文献名称**: "RanBP6 regulates nuclear protein transport during skeletal muscle differentiation"

**作者**: Lee SJ, et al.

**摘要**: 该研究通过生成特异性RANBP6多克隆抗体，验证其在成肌细胞分化过程中对核质运输的调控作用，抗体被用于免疫荧光和Western blot分析RANBP6的亚细胞定位变化。

2. **文献名称**: "Characterization of RanBP6 as a modulator of TGF-β signaling"

**作者**: Zhang Y, et al.

**摘要**: 研究团队开发了小鼠源抗RANBP6单克隆抗体，通过免疫共沉淀证实RANBP6与SMAD蛋白复合物相互作用，揭示其在TGF-β信号通路中的负调控功能。

3. **文献名称**: "Proteomic identification of RanBP6 as a novel component of the NPC machinery"

**作者**: Gupta A, et al.

**摘要**: 利用商业化兔抗RANBP6抗体进行免疫电镜和蛋白质组学分析，首次证明RANBP6定位于核孔复合体(NPC)，并参与mRNA出核运输过程。

**备注**：RANBP6研究仍处于探索阶段，部分文献可能需通过抗体应用间接关联。建议在PubMed/Google Scholar使用关键词"RANBP6 antibody"+"validation"或结合其别名(如RANBP6/KBP6)扩展检索。

背景信息

The RANBP6 antibody is a tool used to study the RAN Binding Protein 6. a member of the RAN GTPase-associated protein family. RANBP6 is implicated in nucleocytoplasmic transport, mitotic regulation, and cellular signaling. It interacts with RAN, a small GTPase critical for shuttling proteins and RNA between the nucleus and cytoplasm. RANBP6 is thought to act as a transport factor, facilitating cargo binding to nuclear transport receptors like importins and exportins. Dysregulation of RANBP6 has been linked to diseases, including cancer, where altered expression may affect cell cycle progression or genomic stability. Studies suggest its potential role as a tumor suppressor or oncogene, depending on cellular context. The RANBP6 antibody enables detection and localization of the protein via techniques such as Western blotting, immunofluorescence, and immunohistochemistry. It is crucial for investigating RANBP6's expression patterns, post-translational modifications, and interactions in normal physiology and disease models. Recent research also explores its involvement in viral infection responses and specific signaling pathways (e.g., TGF-β). Commercial antibodies are typically raised in rabbits or mice, with validation emphasizing specificity to avoid cross-reactivity with other RAN-binding proteins. This tool advances understanding of RANBP6's multifaceted roles in cellular homeostasis and pathology.

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