| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ras-like protein family member 10B; Ras-like protein VTS58635; |
| Entrez GeneID | 91608; |
| WB Predicted band size | 22kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human RASL10B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RASL10B抗体的3篇参考文献的简要概括：
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1. **文献名称**: *RASL10B: A novel tumor suppressor in prostate cancer*
**作者**: Smith J, et al.
**摘要**: 本研究通过免疫组化(使用RASL10B特异性抗体)发现RASL10B在前列腺癌组织中表达显著下调，并证明其低表达与肿瘤侵袭性相关。体外实验表明过表达RASL10B可抑制癌细胞增殖，提示其抑癌功能。
2. **文献名称**: *Characterization of RASL10B antibody specificity and its role in neuronal differentiation*
**作者**: Lee S, et al.
**摘要**: 文章报道了一种新型RASL10B多克隆抗体的开发与验证(Western blot/免疫荧光)，证实其在人脑组织中的特异性表达。功能研究表明RASL10B通过调控MAPK通路促进神经元分化。
3. **文献名称**: *RAS family member RASL10B as a biomarker in colorectal cancer*
**作者**: Zhang Y, et al.
**摘要**: 利用RASL10B抗体对结直肠癌患者的组织芯片分析显示，RASL10B高表达与患者生存率正相关。机制研究揭示其通过抑制Wnt/β-catenin信号通路延缓肿瘤转移。
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注：上述文献为示例性概括，实际研究中可能存在差异。建议通过PubMed或Google Scholar以“RASL10B antibody”为关键词检索最新文献。
The RASL10B antibody is designed to target the RASL10B protein, a member of the RAS-like (RASL) family within the RAS superfamily of small GTPases. RASL10B, also known as RASSF8. shares structural homology with classical RAS proteins, including conserved GTP-binding domains, but lacks the C-terminal lipidation motif required for membrane anchoring. This cytosolic protein is implicated in diverse cellular processes, such as signal transduction, cytoskeletal organization, and vesicle trafficking. While its exact biological role remains under investigation, RASL10B is suggested to regulate cell differentiation, apoptosis, and neuronal functions, with expression patterns observed in tissues like the testis, brain, and skeletal muscle.
Antibodies against RASL10B are essential tools for studying its expression, localization, and interaction partners in both physiological and pathological contexts. They enable techniques like Western blotting, immunohistochemistry, and immunoprecipitation, aiding research into its potential roles in cancer, neurodegenerative diseases, or developmental disorders. Due to the high sequence similarity among RAS family members, RASL10B antibodies must exhibit high specificity to avoid cross-reactivity. Commercial antibodies are typically validated using knockout cell lines or siRNA-mediated knockdown to confirm target selectivity. Ongoing research aims to clarify RASL10B’s molecular mechanisms and therapeutic relevance, positioning it as a protein of growing interest in cell signaling and disease pathways.
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