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Rabbit Polyclonal RDM1 Antibody

  • 中文名： RDM1抗体
  • 别    名： RAD52 homolog B; RAD52 motif-containing protein 1; RAD52B;
货号: IPDX42545
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRAD52 homolog B; RAD52 motif-containing protein 1; RAD52B;
Entrez GeneID201299;
WB Predicted band size32kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human RDM1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于RDM1抗体的参考文献示例(注：以下内容为模拟示例，实际文献可能需要通过学术数据库核实)：

1. **文献名称**：*RDM1 Antibody Characterization in DNA Repair Pathways*

**作者**：Lee, J. et al.

**摘要**：本研究开发并验证了一种高特异性RDM1多克隆抗体，通过Western blot和免疫组化分析，证实RDM1在卵巢癌细胞中参与同源重组修复(HR)，其表达缺失与铂类化疗耐药性相关。

2. **文献名称**：*RDM1 as a Biomarker in Ovarian Cancer Prognosis*

**作者**：Wang, Y. et al.

**摘要**：利用RDM1单克隆抗体检测临床样本，发现RDM1低表达与晚期卵巢癌患者预后不良显著相关，提示其可作为预测DNA损伤治疗反应的潜在标志物。

3. **文献名称**：*Functional Interaction of RDM1 with RAD51 in Genome Stability*

**作者**：Chen, R. et al.

**摘要**：通过免疫共沉淀(使用RDM1抗体)和荧光定位技术，揭示RDM1与RAD51蛋白的相互作用对维持基因组稳定性至关重要，其功能缺陷导致肿瘤细胞对PARP抑制剂敏感。

4. **文献名称**：*RDM1 Antibody Application in Sporadic Breast Cancer Analysis*

**作者**：Martinez, L. et al.

**摘要**：研究通过RDM1抗体检测散发性乳腺癌组织，发现RDM1表达与BRCA1突变状态相关，为个性化治疗策略提供分子依据。

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**注**：以上为模拟文献，实际引用需查询PubMed、Google Scholar等平台(关键词：RDM1 antibody、DNA repair、ovarian cancer)。RDM1蛋白通常与DNA修复及癌症治疗耐药性机制相关，抗体多用于功能研究与临床检测。

背景信息

The RDM1 (RAD52 Motif 1) antibody is a research tool developed to study the RDM1 protein, which plays a role in DNA repair and meiotic recombination. RDM1 was first identified in 2008 as a conserved protein containing a RAD52-like motif, suggesting its involvement in homologous recombination repair (HRR). RAD52 is a key mediator of DNA repair through single-strand annealing (SSA), and RDM1 is hypothesized to interact with RAD52 or function in parallel pathways. Studies indicate that RDM1 participates in replication fork restart and repair of double-strand breaks (DSBs), particularly in contexts where homologous recombination is compromised. It is also implicated in meiosis, with elevated expression in germ cells, hinting at its role in maintaining genomic stability during gametogenesis. Dysregulation of RDM1 has been linked to infertility and cancer susceptibility, as defective DNA repair mechanisms can drive genomic instability. The RDM1 antibody is primarily used in molecular biology to detect protein expression via Western blotting, immunofluorescence, or immunohistochemistry, aiding in investigations of DNA repair dynamics, meiotic defects, and cancer biology. Its application extends to studying synthetic lethality in BRCA-mutated cancers, where RDM1-related pathways may offer therapeutic targets. Research remains ongoing to fully elucidate its molecular interactions and clinical relevance.

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