Rabbit Polyclonal RDM1 Antibody

The RDM1 (RAD52 Motif 1) antibody is a research tool developed to study the RDM1 protein, which plays a role in DNA repair and meiotic recombination. RDM1 was first identified in 2008 as a conserved protein containing a RAD52-like motif, suggesting its involvement in homologous recombination repair (HRR). RAD52 is a key mediator of DNA repair through single-strand annealing (SSA), and RDM1 is hypothesized to interact with RAD52 or function in parallel pathways. Studies indicate that RDM1 participates in replication fork restart and repair of double-strand breaks (DSBs), particularly in contexts where homologous recombination is compromised. It is also implicated in meiosis, with elevated expression in germ cells, hinting at its role in maintaining genomic stability during gametogenesis. Dysregulation of RDM1 has been linked to infertility and cancer susceptibility, as defective DNA repair mechanisms can drive genomic instability. The RDM1 antibody is primarily used in molecular biology to detect protein expression via Western blotting, immunofluorescence, or immunohistochemistry, aiding in investigations of DNA repair dynamics, meiotic defects, and cancer biology. Its application extends to studying synthetic lethality in BRCA-mutated cancers, where RDM1-related pathways may offer therapeutic targets. Research remains ongoing to fully elucidate its molecular interactions and clinical relevance.