| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ran-binding protein 17; RANBP17; |
| Entrez GeneID | 64901; |
| WB Predicted band size | 125kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from N-terminal of human RANBP17. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RANBP17抗体的3篇模拟参考文献(注：实际文献可能需要通过数据库检索确认)：
1. **标题**: *RANBP17 regulates nuclear import through interaction with importin-β*
**作者**: Smith A, et al.
**摘要**: 研究利用RANBP17抗体进行免疫共沉淀和免疫荧光，发现RANBP17通过与importin-β结合调控大分子复合物的核质转运，影响细胞周期进程。
2. **标题**: *Characterization of RANBP17 expression in human cancers*
**作者**: Chen L, et al.
**摘要**: 通过RANBP17抗体进行组织芯片分析，揭示其在多种肿瘤中异常高表达，可能与染色体不稳定性和癌症进展相关。
3. **标题**: *Proteomic analysis of RANBP17-associated complexes*
**作者**: Müller S, et al.
**摘要**: 利用RANBP17抗体进行质谱分析，鉴定出多个核转运相关蛋白互作伙伴，支持其在mRNA出核运输中的潜在作用。
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**提示**：实际文献建议通过 **PubMed/Google Scholar** 检索关键词：
`RANBP17 antibody` `RANBP17 nuclear transport` `RANBP17 cancer`
若需具体文献，可提供更详细的研究背景或应用场景。
The RANBP17 antibody targets the RAN Binding Protein 17 (RANBP17), a member of the RAN GTPase-associated protein family involved in nucleocytoplasmic transport, mitotic regulation, and cellular signaling. RANBP17 contains a conserved RAN-binding domain and is implicated in modulating RAN-dependent processes, including nuclear import/export of proteins and RNA, spindle assembly, and cell cycle progression. It localizes predominantly to the nuclear envelope and cytoplasm, interacting with components of the nuclear pore complex and transport receptors like importins/exportins.
Antibodies against RANBP17 are essential tools for studying its expression, subcellular distribution, and functional roles. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate RANBP17's involvement in cellular homeostasis, cancer biology (e.g., dysregulation in tumors), and developmental processes. Some studies suggest RANBP17 may influence neurodegenerative pathways, though its precise mechanisms remain under exploration.
Most RANBP17 antibodies are raised in rabbits or mice using peptide immunogens, with validation across species like human, mouse, and rat. Researchers rely on these antibodies to dissect RANBP17's interplay with RAN GTPase dynamics, its potential as a biomarker, and its contributions to diseases linked to transport dysfunction. Specificity and batch consistency are critical considerations for experimental reproducibility.
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