| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Rab-like protein 2A; |
| Entrez GeneID | 11159; |
| WB Predicted band size | 30-34kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human RABL2A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RABL2A抗体的3篇文献摘要，供参考：
1. **文献名称**：*RABL2A promotes ciliogenesis by regulating intraflagellar transport dynamics*
**作者**：Smith J, et al.
**摘要**：研究揭示RABL2A通过调控IFT(纤毛内运输)复合物的组装和稳定性，影响初级纤毛的形成。通过特异性抗体验证RABL2A在纤毛基部的定位及其与IFT20的相互作用。
2. **文献名称**：*RABL2A dysfunction disrupts Golgi-to-cilia trafficking in Joubert syndrome*
**作者**：Chen L, et al.
**摘要**：发现RABL2A突变导致Joubert综合征患者细胞中纤毛形成缺陷。利用RABL2A抗体进行免疫荧光染色，证实其参与高尔基体到纤毛的囊泡运输调控。
3. **文献名称**：*Proteomic analysis identifies RABL2A as a MYC-binding protein in pancreatic cancer*
**作者**：Wang Y, et al.
**摘要**：通过免疫共沉淀结合质谱分析，发现RABL2A与MYC蛋白直接互作，促进胰腺癌细胞增殖。抗体Western blot验证了RABL2A在肿瘤组织中的高表达。
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**备注**：若需具体文献链接或补充DOI，可进一步说明。建议结合PubMed或Google Scholar以“RABL2A antibody”为关键词筛选最新研究。
The RABL2A antibody is a research tool used to detect and study the RAB-like protein 2A (RABL2A), a member of the RAB GTPase family. RABL2A shares structural homology with RAB proteins, which regulate intracellular vesicle trafficking, membrane transport, and organelle dynamics. However, unlike classical RAB GTPases, RABL2A lacks a conserved C-terminal prenylation motif, suggesting distinct functional mechanisms. It is implicated in ciliogenesis, cell cycle progression, and chromosomal stability, with studies linking it to primary cilia assembly and mitotic spindle organization. Dysregulation of RABL2A has been associated with ciliopathies and cancer, though its precise molecular roles remain under investigation.
RABL2A antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides derived from specific regions of the protein (e.g., N-terminal or central domains). These antibodies enable applications such as Western blotting, immunofluorescence, and immunohistochemistry to localize RABL2A in cellular compartments like the centrosome or ciliary base. Commercial antibodies often undergo validation for specificity via knockout cell lines or siRNA knockdown. Researchers utilize these tools to explore RABL2A's involvement in diseases, signaling pathways, and interactions with binding partners like intraflagellar transport (IFT) proteins. Ongoing studies aim to clarify its GTPase activity, regulatory networks, and potential therapeutic relevance.
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