| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RALBP1; RALBP1 associated Eps domain containing 1; RalBP1-associated Eps domain-containing protein 1; RalBP1-interacting protein 1; REPS1 |
| Entrez GeneID | 85021; |
| WB Predicted band size | 80kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Synthesized peptide derived from C-terminal of human REPS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于REPS1抗体的3篇代表性文献，包含标题、作者和摘要概要：
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1. **标题**：*REPS1/RalBP1 Interacts with EGFR Signaling to Stabilize the Receptor in Hepatocellular Carcinoma*
**作者**：Chen L, et al.
**摘要**：研究揭示了REPS1通过调控EGFR内吞作用促进肝癌进展，利用特异性REPS1抗体进行免疫共沉淀和Western blot，证实其与EGFR的相互作用，为靶向治疗提供依据。
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2. **标题**：*REPS1 as a Novel Biomarker in Alzheimer’s Disease: Insights from Post-Mortem Brain Analysis*
**作者**：Smith J, et al.
**摘要**：通过免疫组化(使用REPS1抗体)发现阿尔茨海默病患者脑组织中REPS1表达显著降低，提示其可能参与神经退行性病变的突触囊泡运输障碍。
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3. **标题**：*Development of a High-Affinity Monoclonal Antibody Against REPS1 for Functional Studies in Colorectal Cancer*
**作者**：Wang Y, et al.
**摘要**：报道了一种新型REPS1单克隆抗体的开发，验证了其在流式细胞术和免疫荧光中的应用，并发现REPS1高表达与结直肠癌转移相关。
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*注：以上文献信息为示例性内容，实际文献需通过PubMed/Google Scholar检索确认。*
The REPS1 (RALBP1-associated Eps domain-containing protein 1) antibody is a tool used to study the REPS1 protein, which plays roles in intracellular signaling, vesicle trafficking, and receptor endocytosis. REPS1 contains two EH (Eps15 homology) domains and a coiled-coil region, enabling interactions with proteins like RALBP1 (RalA-binding protein 1) and Eps15. These interactions link REPS1 to pathways regulating cell proliferation, apoptosis, and membrane transport.
REPS1 is implicated in diseases such as cancer and neurodegenerative disorders. In cancer, REPS1 may modulate Ras signaling and influence tumor progression by regulating receptor tyrosine kinase internalization. In Alzheimer’s disease, it interacts with amyloid precursor protein (APP), suggesting a role in amyloidogenic processing. The REPS1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression, localization, and molecular interactions in cellular and tissue samples.
Current research focuses on clarifying REPS1’s precise mechanisms, including its involvement in stress response and synaptic function. The antibody aids in exploring its potential as a biomarker or therapeutic target. However, challenges remain in understanding tissue-specific isoforms and post-translational modifications, necessitating further validation of antibody specificity across experimental models.
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