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Rabbit Polyclonal CAPN12 Antibody

  • 中文名： CAPN12抗体
  • 别    名： Calpain-12; Calcium-activated neutral proteinase 12; CANP 12;
货号: IPDX42328
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCalpain-12; Calcium-activated neutral proteinase 12; CANP 12;
Entrez GeneID147968;
WB Predicted band size80kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from internal of human CAPN12.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于CAPN12抗体的假设性参考文献示例(实际文献可能需要根据最新研究补充或核实)：

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1. **文献名称**：*Calpain-12 Expression in Epidermal Differentiation: A Role in Skin Barrier Function*

**作者**：Smith A, et al.

**摘要**：本研究利用CAPN12特异性抗体，通过免疫组化和Western blot技术，揭示了CAPN12在小鼠表皮角质形成细胞中的高表达。结果表明，CAPN12可能通过调控细胞间连接蛋白的加工参与皮肤屏障的形成。

2. **文献名称**：*CAPN12 Antibody Validation for Immunohistochemical Staining in Human Tissues*

**作者**：Lee H, et al.

**摘要**：文章系统验证了CAPN12抗体在多种人类组织中的特异性，发现其在胃肠道和生殖系统中呈现显著表达，并提示其可能参与黏膜免疫调节及细胞凋亡通路。

3. **文献名称**：*Role of CAPN12 in Colorectal Cancer Progression: Insights from Antibody-Based Proteomic Analysis*

**作者**：Wang X, et al.

**摘要**：通过CAPN12抗体检测结直肠癌组织样本，发现其表达水平与肿瘤侵袭性呈负相关，提示CAPN12可能作为抑癌因子通过抑制基质金属蛋白酶活性发挥作用。

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**备注**：以上文献为示例，实际研究中CAPN12相关抗体文献可能较少，建议通过PubMed或抗体生产商(如Abcam、Cell Signaling Technology)的技术文档获取最新信息。

背景信息

The calpain family comprises calcium-dependent cysteine proteases involved in diverse cellular processes, including signal transduction, apoptosis, and cytoskeletal remodeling. CAPN12 (calpain-12), a less-characterized member, is distinguished by its tissue-specific expression, notably in the skin, hair follicles, and intestinal epithelium. Unlike other calpains, CAPN12 lacks a calcium-binding domain, suggesting unique regulatory mechanisms. It is implicated in epithelial cell differentiation, barrier function, and possibly inflammatory or neoplastic conditions. CAPN12 antibodies are essential tools for detecting and studying this protein's expression, localization, and functional roles. Developed using immunogenic peptide sequences or recombinant protein fragments, these antibodies enable applications like Western blotting, immunohistochemistry, and immunofluorescence. Research utilizing CAPN12 antibodies has explored its potential involvement in skin disorders, gut homeostasis, and cancer progression. However, challenges persist in validating antibody specificity due to high homology among calpain isoforms and limited commercial availability. Recent studies emphasize CAPN12's non-proteolytic roles, such as modulating cell adhesion or signaling pathways, expanding its biological significance. Reliable CAPN12 antibodies remain critical for unraveling its physiological and pathological contributions, offering insights into therapeutic targeting in epithelial-related diseases.

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