Rabbit Polyclonal CAPN12 Antibody

The calpain family comprises calcium-dependent cysteine proteases involved in diverse cellular processes, including signal transduction, apoptosis, and cytoskeletal remodeling. CAPN12 (calpain-12), a less-characterized member, is distinguished by its tissue-specific expression, notably in the skin, hair follicles, and intestinal epithelium. Unlike other calpains, CAPN12 lacks a calcium-binding domain, suggesting unique regulatory mechanisms. It is implicated in epithelial cell differentiation, barrier function, and possibly inflammatory or neoplastic conditions. CAPN12 antibodies are essential tools for detecting and studying this protein's expression, localization, and functional roles. Developed using immunogenic peptide sequences or recombinant protein fragments, these antibodies enable applications like Western blotting, immunohistochemistry, and immunofluorescence. Research utilizing CAPN12 antibodies has explored its potential involvement in skin disorders, gut homeostasis, and cancer progression. However, challenges persist in validating antibody specificity due to high homology among calpain isoforms and limited commercial availability. Recent studies emphasize CAPN12's non-proteolytic roles, such as modulating cell adhesion or signaling pathways, expanding its biological significance. Reliable CAPN12 antibodies remain critical for unraveling its physiological and pathological contributions, offering insights into therapeutic targeting in epithelial-related diseases.