| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BAI1-associated protein 2-like 2; BI2L2; brain-specific angiogenesis inhibitor 1-associated 2-like 2; |
| Entrez GeneID | 80115; |
| WB Predicted band size | 52kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human BAIAP2L2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于BAIAP2L2抗体的3篇参考文献示例(注：文献为虚构示例，供参考格式)：
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1. **文献名称**：*BAIAP2L2 regulates dendritic spine formation through actin remodeling in neuronal cells*
**作者**：Lee, S. et al.
**摘要**：本研究利用特异性BAIAP2L2抗体进行免疫印迹和免疫荧光实验，揭示BAIAP2L2通过调控肌动蛋白聚合促进神经元树突棘发育，为神经突触可塑性提供分子机制依据。
2. **文献名称**：*Development of a high-affinity monoclonal antibody against BAIAP2L2 for cancer biomarker studies*
**作者**：Wang, X. et al.
**摘要**：报道了一种新型BAIAP2L2单克隆抗体的开发与验证，通过ELISA和免疫组化证实其特异性，并应用于乳腺癌样本检测，发现BAIAP2L2表达与肿瘤侵袭性正相关。
3. **文献名称**：*BAIAP2L2 interacts with EGFR to modulate tumor cell migration in glioblastoma*
**作者**：Garcia, M. et al.
**摘要**：通过免疫共沉淀(使用BAIAP2L2抗体)和功能实验，证明BAIAP2L2与EGFR相互作用，增强胶质母细胞瘤细胞的迁移能力，提示其作为治疗靶点的潜力。
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如需真实文献，建议在PubMed或Web of Science中以“BAIAP2L2 antibody”为关键词检索，并筛选涉及抗体开发、验证或应用的实验研究。
BAIAP2L2 (BAI1-associated protein 2-like 2), also known as IRTKS (insulin receptor tyrosine kinase substrate), is a member of the BAIAP2 protein family characterized by its conserved IMD (IRSp53/MIM homology domain) and SH3 (Src homology 3) domains. It plays a role in membrane curvature sensing, cytoskeletal remodeling, and cellular signaling pathways. BAIAP2L2 interacts with small GTPases like CDC42 and Rac1. linking membrane dynamics to actin reorganization, which is critical for processes such as filopodia formation, cell migration, and endocytosis.
The antibody against BAIAP2L2 is a valuable tool for studying its expression, localization, and function in various biological contexts. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect BAIAP2L2 in tissues or cultured cells. Research has implicated BAIAP2L2 in cancer progression, particularly in tumors with enhanced metastatic potential, where its overexpression may promote invasiveness by modulating cytoskeletal architecture. Additionally, studies suggest its involvement in neuronal development and synaptic plasticity due to its expression in brain tissues.
Developed in multiple host species (e.g., rabbit, mouse), BAIAP2L2 antibodies are essential for exploring its role in disease mechanisms and validating interactions with binding partners. Proper validation via knockout controls or peptide blocking ensures specificity, supporting its application in both basic research and clinical investigations.
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