| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calpain-11; Calcium-activated neutral proteinase 11; CANP 11; |
| Entrez GeneID | 11131; |
| WB Predicted band size | 81kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CAPN11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于CAPN11抗体的假设性参考文献示例(实际文献需根据具体数据库检索验证)：
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**1. 文献名称**: *"Characterization of CAPN11-Specific Antibodies for Studying Testicular Spermatogenesis Regulation"*
**作者**: Zhang L, et al.
**摘要**: 本研究开发了针对CAPN11蛋白的高效多克隆抗体，通过免疫印迹和免疫组化验证其在哺乳动物睾丸组织中的特异性表达。结果表明CAPN11在精子发生后期阶段显著上调，提示其在减数分裂调控中的潜在作用。
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**2. 文献名称**: *"CAPN11 Expression in Ovarian Cancer: A Novel Biomarker Identified by Monoclonal Antibody Staining"*
**作者**: Tanaka K, et al.
**摘要**: 利用新开发的抗CAPN11单克隆抗体，研究者发现CAPN11在卵巢癌组织中的异常高表达，并与患者预后不良相关。抗体特异性经siRNA敲除实验验证，为CAPN11作为治疗靶点提供了依据。
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**3. 文献名称**: *"Role of CAPN11 in Adipocyte Differentiation: Insights from Antibody-Mediated Functional Blockade"*
**作者**: Gupta R, et al.
**摘要**: 通过CAPN11中和抗体抑制其活性，研究发现CAPN11缺失会阻碍脂肪细胞分化关键基因(如PPARγ)的表达，表明其在脂肪生成中的调控功能，为代谢疾病研究提供新方向。
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**注**：以上为模拟示例，实际文献需通过PubMed、Web of Science等平台以“CAPN11 antibody”或“calpain 11”为关键词检索。若需具体文献，建议补充研究背景(如物种、应用场景)以便精准推荐。
**Background of CAPN11 Antibody**
Calpain-11 (CAPN11) is a member of the calpain family of calcium-dependent cysteine proteases, which regulate diverse cellular processes such as signal transduction, apoptosis, and cytoskeletal remodeling. Unlike classical calpains (e.g., CAPN1/2), CAPN11 exhibits distinct structural features, including a unique C-terminal domain, suggesting specialized roles in specific tissues or pathways. It is evolutionarily conserved and implicated in reproductive biology, particularly spermatogenesis and placental development, though its precise molecular mechanisms remain poorly characterized.
CAPN11 antibodies are immunological tools designed to detect and study the expression, localization, and function of the CAPN11 protein. These antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides derived from conserved regions of CAPN11. They enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore CAPN11's tissue-specific expression patterns, particularly in testes, ovaries, and certain cancer types.
Research using CAPN11 antibodies has revealed its potential involvement in pathological conditions, including malignancies and metabolic disorders. For example, aberrant CAPN11 expression has been linked to tumor progression in some cancers, hinting at its role as a biomarker or therapeutic target. However, validation of antibody specificity and cross-reactivity remains critical due to structural similarities among calpain family members. Ongoing studies aim to clarify CAPN11's physiological and pathological significance, leveraging these antibodies to uncover its interactions with substrates and regulatory pathways.
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