| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520; CHP2; HCA520; |
| Entrez GeneID | 63928; |
| WB Predicted band size | 22kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of humanCHP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CHP2抗体的3篇参考文献的简要总结(文献信息为模拟示例，非真实存在)：
1. **文献名称**：*CHP2 regulates cancer cell proliferation via interaction with Na+/H+ exchanger 1*
**作者**：Matsushita, K., et al.
**摘要**：该研究报道了CHP2通过与钠氢交换体NHE1结合，促进癌细胞内的pH稳态，从而加速细胞周期进程。使用特异性CHP2抗体验证了其在多种癌细胞系中的高表达，并表明其过表达与肿瘤生长相关。
2. **文献名称**：*Calcineurin Homologous Protein 2 (CHP2) modulates cardiac hypertrophy through calcium signaling pathways*
**作者**：Hawkins, B.J., et al.
**摘要**：研究利用CHP2抗体在小鼠模型中发现，CHP2通过调控钙调神经磷酸酶信号通路参与心肌肥厚的发展，敲低CHP2可缓解病理性的心脏肥大。
3. **文献名称**：*Development of a monoclonal antibody specific to CHP2 for diagnostic applications*
**作者**：Chen, L., et al.
**摘要**：该文献描述了一种新型CHP2单克隆抗体的开发，验证了其在免疫组化和Western blot中的高特异性，并证实其在结直肠癌组织中可作为潜在诊断标志物。
注：以上内容为模拟示例，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。
The CHP2 (Calcium Homolog Protein 2) antibody is a tool used to detect and study the CHP2 protein, a member of the CHP family of calcium-binding regulatory proteins. CHP2 shares structural similarity with calcineurin B and is involved in calcium-dependent signaling pathways. It interacts with sodium/proton exchangers (NHEs), particularly NHE1. modulating their activity to regulate intracellular pH and ion homeostasis. CHP2 is expressed in various tissues, with higher levels observed in proliferating cells, suggesting roles in cell cycle progression, survival, and cancer biology. Studies link CHP2 overexpression to certain cancers, including colorectal and breast cancers, where it may promote tumor growth and metastasis.
The CHP2 antibody, typically developed in hosts like rabbits or mice, enables researchers to investigate the protein's expression, localization, and interactions via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Its applications extend to exploring CHP2's functional mechanisms in diseases, particularly its interplay with oncogenic signaling pathways. Commercial CHP2 antibodies are often validated for specificity and sensitivity, supporting both basic research and potential clinical biomarker studies. Understanding CHP2's role through antibody-based assays contributes to insights into cellular regulation and therapeutic targeting in cancer and other pathologies.
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