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Rabbit Polyclonal ALS2CR8 Antibody

  • 中文名: ALS2CR8抗体
  • 别    名: Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; Calcium-response factor; CaRF; Testis development protein NYD-SP24;
货号: IPDX42272
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAmyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; Calcium-response factor; CaRF; Testis development protein NYD-SP24;
Entrez GeneID79800;
WB Predicted band size85kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human ALS2CR8.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ALS2CR8抗体的3篇参考文献示例(注:因该基因研究较少,部分内容为假设性概括,建议核实具体文献):

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1. **文献名称**: *ALS2CR8 regulates neuronal autophagy via mTOR signaling pathway*

**作者**: Li X, et al.

**摘要**: 本研究通过ALS2CR8抗体检测发现,ALS2CR8通过抑制mTOR通路激活神经元自噬,其表达下调与ALS模型中的运动神经元退化相关。

2. **文献名称**: *Characterization of ALS2CR8 antibody specificity in neurodegenerative disease models*

**作者**: Smith J, et al.

**摘要**: 文章验证了ALS2CR8抗体的特异性,证明其在人脑组织和小鼠模型中可特异性识别ALS2CR8蛋白,并发现该蛋白在脊髓运动神经元中显著富集。

3. **文献名称**: *ALS2CR8 interacts with RNA-binding proteins in ALS pathogenesis*

**作者**: Wang Y, et al.

**摘要**: 利用ALS2CR8抗体进行免疫共沉淀实验,发现其与TDP-43和FUS等RNA结合蛋白存在相互作用,提示其在ALS相关RNA代谢异常中的潜在作用。

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**注意**:以上文献为示例,实际研究中ALS2CR8的相关报道较少。若需真实文献,建议通过PubMed或Google Scholar以“ALS2CR8 antibody”或“ALS2CR8 function”为关键词检索,并筛选近年的功能研究或抗体开发类论文。

背景信息

The ALS2CR8 antibody is designed to target the ALS2CR8 protein, a product of the ALS2CR8 gene located on human chromosome 2. While the precise biological function of ALS2CR8 remains under investigation, it is hypothesized to play roles in cellular processes such as RNA metabolism, intracellular trafficking, or signal transduction, based on structural homology to related proteins in the Alsin family (ALS2). ALS2 mutations are linked to neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia, suggesting potential relevance of ALS2CR8 in neurobiology. The ALS2CR8 antibody is primarily utilized in research to detect and quantify the protein’s expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Its development aids in exploring ALS2CR8’s localization, interaction partners, and potential involvement in disease pathways. While not yet directly associated with clinical applications, this antibody serves as a critical tool for elucidating ALS2CR8’s physiological and pathological contributions, particularly in neurodegeneration studies. Further validation of its specificity and functional utility in model systems is ongoing to clarify its role in health and disease.

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