Rabbit Polyclonal SCNN1D Antibody

The SCNN1D gene encodes the delta subunit of the epithelial sodium channel (ENaC), a critical ion channel involved in sodium reabsorption and fluid balance. ENaC, composed of α, β, γ, or δ subunits, regulates transepithelial sodium transport in tissues like the kidneys, lungs, and colon. The δ subunit (SCNN1D) is less characterized than other subunits but shares structural homology with the α subunit, suggesting overlapping roles in sodium homeostasis. SCNN1D is expressed in specific tissues, including the pancreas, ovaries, and lungs, and may contribute to unique ENaC functions in these regions. Antibodies targeting SCNN1D are essential tools for studying its expression, localization, and physiological or pathological roles. Dysregulation of ENaC activity, including potential δ subunit involvement, is linked to diseases such as hypertension, cystic fibrosis, and electrolyte imbalances. SCNN1D-specific antibodies enable researchers to investigate its interaction with other ENaC subunits, post-translational modifications, and responses to hormonal signals (e.g., aldosterone). These antibodies are also used in diagnostic research to explore SCNN1D mutations associated with rare genetic disorders like pseudohypoaldosteronism or Liddle syndrome. Developing high-specificity, validated SCNN1D antibodies remains crucial for advancing understanding of ENaC diversity and therapeutic targeting.