Rabbit Polyclonal NECAB3 Antibody

The NECAB3 (N-terminal EF-hand Calcium-binding protein 3) antibody is a tool used to detect and study the expression of the NECAB3 protein, a member of the EF-hand calcium-binding protein family. NECAB3 is characterized by two EF-hand calcium-binding motifs at its N-terminus, enabling it to interact with calcium ions and participate in calcium-mediated signaling pathways. Predominantly expressed in the brain, particularly in neurons, NECAB3 is implicated in regulating synaptic plasticity, neurotransmitter release, and intracellular calcium homeostasis. Its interaction with other neuronal proteins, such as PSD-95. suggests roles in synaptic organization and signal transduction. Dysregulation of NECAB3 has been explored in neurological disorders, including Alzheimer’s disease and schizophrenia, where calcium signaling disruptions are common. Additionally, NECAB3 expression has been observed in non-neuronal tissues, though its functions there remain less understood. The NECAB3 antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to map protein distribution, assess expression levels in disease models, and investigate its molecular interactions. Validated for specificity, this antibody aids in uncovering NECAB3’s physiological and pathological roles, offering insights into calcium-dependent mechanisms in health and disease. Ongoing research aims to clarify its potential as a therapeutic target or biomarker for neurological and other disorders.