Rabbit Polyclonal ALS2CR4 Antibody

The ALS2CR4 antibody is associated with the study of the ALS2 (Alsin Rho guanine nucleotide exchange factor) gene region, particularly targeting the candidate gene ALS2CR4. ALS2 is linked to autosomal recessive forms of amyotrophic lateral sclerosis (ALS), juvenile primary lateral sclerosis (JPLS), and infantile-onset ascending hereditary spastic paralysis (IAHSP). While ALS2 itself encodes a protein involved in neuronal maintenance and intracellular trafficking, ALS2CR4 is a less-characterized candidate gene within the same chromosomal region (2q33.2). Its exact biological function remains unclear, though it is hypothesized to play a role in neurodegenerative pathways or cellular processes overlapping with ALS2. Antibodies against ALS2CR4 are primarily utilized in research to investigate its expression patterns, subcellular localization, and potential interactions in neural tissues or disease models. Such studies aim to clarify its contribution to motor neuron diseases or its regulatory relationship with ALS2. Despite limited clinical data, ALS2CR4 antibodies serve as tools for exploring genetic and molecular mechanisms underlying ALS-related disorders. Ongoing research focuses on validating its pathological relevance and utility as a biomarker or therapeutic target in neurodegeneration.