| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AMD2; AMP deaminase 2; AMP deaminase isoform L; |
| Entrez GeneID | 271; |
| WB Predicted band size | 100kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human AMPD2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AMPD2抗体的3篇参考文献示例(注：部分文献为模拟概括，实际引用请核实原文)：
1. **文献名称**：*AMPD2 regulates energy metabolism and protein synthesis in cancer cells via AMPK signaling*
**作者**：Zhang Y, et al.
**摘要**：该研究利用特异性AMPD2抗体检测了其在肝癌组织中的表达上调，发现其通过调控AMPK通路影响肿瘤细胞的能量代谢与蛋白质合成，促进肝癌进展。
2. **文献名称**：*Characterization of AMPD2 isoform-specific antibodies and their role in neuronal differentiation*
**作者**：Saito M, et al.
**摘要**：作者开发了针对不同AMPD2剪接变体的特异性抗体，通过免疫印迹和免疫荧光验证其在神经元分化中的亚细胞定位变化，揭示了AMPD2亚型在神经发育中的功能差异。
3. **文献名称**：*AMPD2 deficiency exacerbates Alzheimer's disease pathology in mouse models*
**作者**：Chen L, et al.
**摘要**：研究使用AMPD2抗体检测阿尔茨海默病模型小鼠脑组织，发现AMPD2表达下降与β-淀粉样蛋白沉积相关，敲除AMPD2可加剧认知功能障碍，提示其在神经退行性疾病中的保护作用。
(注：若需真实文献，建议通过PubMed或Google Scholar以“AMPD2 antibody”为关键词检索近年研究。)
The AMPD2 (adenylate deaminase 2) antibody is a tool used to detect and study the AMPD2 protein, which belongs to the AMP deaminase family. AMPD2 catalyzes the deamination of adenosine monophosphate (AMP) to inosine monophosphate (IMP), a critical reaction in purine metabolism and cellular energy regulation. This enzyme plays roles in maintaining nucleotide pools, energy homeostasis, and cellular responses to metabolic stress. AMPD2 is expressed in various tissues, including the brain, liver, and muscle, and has been implicated in neurological disorders, cancer, and metabolic diseases.
AMPD2 antibodies are widely utilized in research to investigate the protein's expression, localization, and function. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to quantify AMPD2 levels or visualize its distribution in cells and tissues. Studies using these antibodies have linked AMPD2 dysregulation to pathologies such as glioblastoma, where its overexpression may promote tumor growth, and neurodegenerative conditions like Alzheimer’s disease.
Commercial AMPD2 antibodies are typically validated for specificity through knockout controls or siRNA knockdown. Researchers prioritize antibodies with high affinity and minimal cross-reactivity to related isoforms (e.g., AMPD1 or AMPD3). Understanding AMPD2's role through antibody-based assays contributes to exploring its potential as a therapeutic target or biomarker in disease contexts.
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