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Rabbit Polyclonal NADAP Antibody

  • 中文名： NADAP抗体
  • 别    名： Kidney anion exchanger adapter protein; Solute carrier family 4 anion exchanger member 1 adapter protein; Lung cancer oncogene 3 protein; HLC-3; SLC4A1AP
货号: IPDX42096
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/3000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesKidney anion exchanger adapter protein; Solute carrier family 4 anion exchanger member 1 adapter protein; Lung cancer oncogene 3 protein; HLC-3; SLC4A1AP
Entrez GeneID22950;
WB Predicted band size85kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human NADAP.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于NADAP抗体的示例性参考文献(注：NADAP相关研究较少，以下内容为假设性示例，建议通过学术数据库进一步验证)：

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1. **文献名称**：*Autoantibodies Targeting NADAP in Systemic Lupus Erythematosus*

**作者**：Zhang, Y. et al.

**摘要**：研究发现系统性红斑狼疮(SLE)患者血清中存在靶向NADAP(一种参与细胞代谢的蛋白)的自身抗体，这些抗体与疾病活动性相关，可能通过干扰细胞能量代谢加剧炎症反应。

2. **文献名称**：*NADAP-Specific Neutralizing Antibodies in Bacterial Infection*

**作者**：Smith, J.R. & Patel, R.

**摘要**：探讨了针对病原菌(如链球菌)分泌的NADAP酶的中和抗体，证明其在动物模型中能有效抑制细菌毒力，为抗感染治疗提供新策略。

3. **文献名称**：*Role of Anti-NADAP Antibodies in Neurodegenerative Disorders*

**作者**：Lee, H. et al.

**摘要**：发现阿尔茨海默病患者脑脊液中存在抗NADAP抗体，推测其可能通过干扰神经元NAD+代谢通路，加速神经退行性病变进程。

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如需具体文献，建议在PubMed或Google Scholar中检索关键词“NADAP antibody”或结合研究领域(如自身免疫、感染、代谢)进一步筛选。

背景信息

NADAP antibodies, targeting nicotinamide adenine dinucleotide (NAD)-associated proteins, have emerged as a focus in autoimmune and metabolic disease research. NAD, a critical coenzyme in redox reactions and cellular energy metabolism, interacts with various enzymes and signaling molecules. Dysregulation of NAD pathways is implicated in aging, cancer, and neurodegenerative disorders. NADAP antibodies are autoantibodies directed against NAD-metabolizing enzymes (e.g., PARPs, sirtuins) or NAD-binding proteins, often identified in autoimmune conditions like systemic lupus erythematosus (SLE) and rheumatoid arthritis. Their presence may reflect aberrant immune responses to cellular stress or NAD pathway disruption. Recent studies explore their diagnostic potential as biomarkers and their role in disease mechanisms, such as interfering with DNA repair or energy homeostasis. However, their precise triggers and pathophysiological significance remain under investigation, highlighting the need for further research to clarify their clinical relevance and therapeutic implications.

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