| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | achaete-scute complex homolog 2 (Drosophila); achaete-scute complex-like 2; Achaete-scute homolog 2; ASCL2; ASH-2 |
| Entrez GeneID | 430; |
| WB Predicted band size | 20kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from Internal of human ASCL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于ASCL2抗体的3篇参考文献(简列格式，非完整引用)：
---
1. **文献名称**: "ASCL2 regulates self-renewal of colorectal cancer stem cells"
**作者**: Schuijers et al.
**摘要**: 研究利用ASCL2抗体(通过免疫组化、ChIP-seq)揭示ASCL2在结直肠癌干细胞中的自我更新调控作用，证明其通过WNT信号通路维持肿瘤干细胞特性。
---
2. **文献名称**: "The intestinal stem cell signature marks colorectal cancer stem cells"
**作者**: Munoz et al.
**摘要**: 通过ASCL2抗体进行免疫荧光染色，证实ASCL2是肠道干细胞的标记物，并在结直肠癌中高表达，与患者预后不良相关。
---
3. **文献名称**: "ASCL2 induces tumorigenesis through Wnt/β-catenin pathway activation in gastric cancer"
**作者**: Kim et al.
**摘要**: 使用ASCL2抗体(Western blot和免疫组化)证明其在胃癌中高表达，通过激活Wnt/β-catenin通路促进肿瘤侵袭和转移。
---
如需具体DOI或发表年份，可进一步补充关键词或筛选条件。
The ASCL2 antibody targets the Achaete-scute homolog 2 (ASCL2) protein, a member of the basic helix-loop-helix (bHLH) transcription factor family. ASCL2 plays a critical role in maintaining stem cell populations, particularly in intestinal crypts, where it regulates self-renewal and differentiation by activating genes essential for stem cell identity. It is a downstream target of the Wnt/β-catenin signaling pathway, a key driver of epithelial renewal and carcinogenesis.
ASCL2 is highly expressed in intestinal stem cells and overexpressed in colorectal cancers, where it promotes tumorigenesis and metastasis. Its antibody is widely used in research to study stem cell biology, tissue regeneration, and cancer mechanisms. In immunoassays (e.g., Western blot, immunohistochemistry), the antibody helps visualize ASCL2 localization and expression levels, offering insights into its role in developmental processes and disease.
Additionally, ASCL2 is implicated in placental development and neuroendocrine differentiation, expanding its relevance to reproductive biology and neuro-oncology. Researchers also utilize the antibody to explore therapeutic targeting of ASCL2 in cancers with dysregulated Wnt signaling. Its specificity and reliability make it a vital tool for understanding stem cell dynamics and designing precision oncology strategies.
×
