| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nuclear receptor-interacting protein 2; NRIP2; |
| Entrez GeneID | 83714; |
| WB Predicted band size | 26kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from N-terminal of human NRIP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NRIP2抗体的3篇参考文献示例(注：以下内容为虚构示例，实际文献需通过学术数据库查询)：
1. **文献名称**: *"Characterization of a Novel Monoclonal Antibody Against NRIP2 for Detecting Protein Localization in Neuronal Cells"*
**作者**: Zhang Y, et al.
**摘要**: 本研究开发了一种针对NRIP2的单克隆抗体，通过免疫印迹和免疫荧光验证其特异性，发现NRIP2在大鼠海马神经元中主要定位于突触后区域，提示其参与突触可塑性调控。
2. **文献名称**: *"NRIP2 Antibody-Based Analysis Reveals Its Role in Adipose Tissue Inflammation"*
**作者**: Tanaka K, et al.
**摘要**: 利用NRIP2抗体进行组织芯片分析，发现肥胖模型中NRIP2在脂肪组织巨噬细胞中表达升高，并通过NF-κB通路促进炎症反应，为代谢疾病治疗提供新靶点。
3. **文献名称**: *"Validation of a Commercial NRIP2 Antibody for Flow Cytometry Applications in T-Cell Studies"*
**作者**: Müller S, et al.
**摘要**: 评估了某商业NRIP2抗体在流式细胞术中的适用性，证实其可特异性识别T细胞亚群中的NRIP2蛋白，并发现NRIP2表达与T细胞活化程度呈正相关。
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如需真实文献，建议在 **PubMed** 或 **Google Scholar** 中检索关键词“NRIP2 antibody”、“NRIP2 immunohistochemistry”或“NRIP2 protein expression”，筛选涉及抗体开发、验证或应用的实验性研究。
The Nuclear Receptor Interacting Protein 2 (NRIP2), also known as RIP140 (Receptor-Interacting Protein 140), is a transcriptional coregulator that modulates the activity of nuclear receptors, which are critical for regulating gene expression in processes like metabolism, reproduction, and development. NRIP2 interacts with various nuclear receptors, including estrogen receptors (ER), thyroid hormone receptors (TR), and peroxisome proliferator-activated receptors (PPARs), acting as both a coactivator and corepressor depending on cellular context. Its role in energy homeostasis, adipogenesis, and ovarian function has made it a focus in studies of metabolic disorders, obesity, and reproductive health.
NRIP2 antibodies are essential tools for investigating its expression, localization, and molecular interactions. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to detect NRIP2 in tissues and cell lines. They also facilitate chromatin immunoprecipitation (ChIP) assays to study NRIP2’s involvement in gene regulation. Commercially available NRIP2 antibodies are often developed in rabbit or mouse hosts, with specificity validated via knockout cell lines or siRNA knockdown. Research applications span cancer biology (e.g., breast and ovarian cancer), metabolic studies, and reproductive health, reflecting NRIP2’s diverse regulatory roles. Reliable antibodies are critical for elucidating its mechanisms in disease pathways and potential therapeutic targeting.
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