Rabbit Polyclonal MMTA2 Antibody

The MMTA2 (Metastasis-associated protein 2) antibody is a research tool used to study the MTA2 protein, a key component of the NuRD (Nucleosome Remodeling and Deacetylation) complex involved in epigenetic regulation. MTA2. part of the MTA family, acts as a transcriptional co-regulator, modulating chromatin remodeling and gene expression by recruiting histone deacetylases (HDACs) and other chromatin-modifying enzymes. It plays a dual role in cancer biology: while it suppresses certain oncogenic pathways, it also promotes tumor progression and metastasis by enhancing cell invasion and epithelial-mesenchymal transition (EMT). The MMTA2 antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect MTA2 expression levels in tissues or cell lines, particularly in cancer research. Studies have linked MTA2 overexpression to aggressive phenotypes in breast, colorectal, and prostate cancers, making it a potential biomarker for prognosis and a target for therapeutic intervention. Its role in DNA repair and stress response pathways further underscores its importance in cellular homeostasis. Researchers rely on this antibody to explore MTA2's molecular interactions, regulatory mechanisms, and implications in disease models, advancing insights into cancer metastasis and epigenetic therapies.