| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EC 2.7.11.25; M3K6; MAPKKK6; Mitogen-activated protein kinase kinase kinase 6; kinase MAP3K6 |
| Entrez GeneID | 9064; |
| WB Predicted band size | 143kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human MAP3K6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MAP3K6抗体的3篇示例文献(注：以下为虚构示例，实际文献需通过学术数据库查询)：
1. **文献名称**：*MAP3K6 regulates apoptosis in hepatocellular carcinoma via JNK signaling pathway*
**作者**：Chen L, Wang Y, et al.
**摘要**：本研究利用MAP3K6特异性抗体，通过免疫印迹和免疫组化技术，证实MAP3K6在肝癌组织中高表达，并通过激活JNK通路抑制肿瘤细胞凋亡，提示其作为潜在治疗靶点。
2. **文献名称**：*A novel role of MAP3K6 in neuroinflammation and its interaction with TLR4*
**作者**：Smith J, Patel R, et al.
**摘要**：通过基因敲除小鼠模型及MAP3K6抗体阻断实验，发现MAP3K6通过调控TLR4信号通路促进小胶质细胞炎症反应，为神经退行性疾病提供机制新见解。
3. **文献名称**：*Development and validation of a monoclonal antibody targeting human MAP3K6 for functional studies*
**作者**：Zhang H, Liu X, et al.
**摘要**：本文报道了一种高特异性抗MAP3K6单克隆抗体的开发，验证其在流式细胞术、免疫沉淀中的有效性，并用于探究MAP3K6在T细胞活化中的调控作用。
如需真实文献，建议在PubMed或Google Scholar中检索关键词“MAP3K6 antibody”或“MAP3K6 function”。
The MAP3K6 antibody is a crucial tool for studying the mitogen-activated protein kinase kinase kinase 6 (MAP3K6), also known as ASK2 (Apoptosis Signal-regulating Kinase 2). MAP3K6 is a serine/threonine kinase within the MAPK signaling cascade, which regulates cellular responses to stress, inflammation, and apoptosis. It functions upstream of MAP2K/MAPK pathways, often interacting with MAP3K5 (ASK1) to form hetero-oligomers that activate downstream effectors like JNK and p38 kinases. Dysregulation of MAP3K6 has been implicated in metabolic disorders, neurodegenerative diseases, and cancer, highlighting its role in maintaining cellular homeostasis.
The antibody specifically targets MAP3K6. enabling detection and quantification in various experimental setups, including Western blotting, immunohistochemistry, and immunofluorescence. Researchers use it to investigate MAP3K6 expression patterns, post-translational modifications, and interactions under physiological or pathological conditions. Validated antibodies often undergo specificity tests (e.g., knockout cell line validation) to ensure minimal cross-reactivity with related kinases like MAP3K5. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyoclonal) vary, influencing applications in basic research or therapeutic development. MAP3K6 antibodies are pivotal for unraveling stress-responsive signaling mechanisms and exploring potential therapeutic targets in diseases linked to MAPK pathway dysregulation.
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