Rabbit Polyclonal DGKI Antibody

DGKI (diacylglycerol kinase iota) is an enzyme belonging to the DGK family, which regulates cellular signaling by converting diacylglycerol (DAG) into phosphatidic acid (PA), modulating lipid-mediated pathways. DGKI, specifically, is implicated in diverse physiological processes, including immune response, neuronal function, and cancer progression. Its antibody serves as a critical tool for studying DGKI's expression, localization, and mechanistic roles. Research highlights DGKI's involvement in T-cell receptor signaling, where it fine-tunes DAG levels to influence immune activation or anergy. In cancer, DGKI overexpression has been linked to tumor growth and metastasis, potentially through PA-dependent signaling cascades. Neurodegenerative studies suggest its role in synaptic plasticity and neuronal survival. Commercially available DGKI antibodies (polyclonal/monoclonal) enable applications like Western blotting, immunofluorescence, and immunohistochemistry, aiding in disease biomarker discovery and therapeutic target validation. Recent studies also explore DGKI's interaction with RAS proteins and its impact on oncogenic pathways. Despite progress, DGKI's tissue-specific functions and regulatory networks remain incompletely understood, driving ongoing research to clarify its pathophysiological significance across diseases.