Rabbit Polyclonal FIR Antibody

FIR (FBP Interacting Repressor) antibodies are essential tools for studying the multifaceted roles of the FIR protein, a critical regulator of gene expression. Initially identified as a transcriptional repressor interacting with the Far Upstream Element-Binding Protein (FBP), FIR modulates c-MYC expression by competing with FBP for binding to the FUSE element in the c-MYC promoter. This interaction highlights FIR's involvement in cell proliferation and oncogenesis, particularly in cancers like colorectal carcinoma, where its dysregulation is observed. Beyond transcription, FIR (also known as PUF60 or Siah-BP1) functions as a splicing factor, influencing mRNA processing and maintaining genomic stability. It interacts with proteins such as p53 and Siah-1. linking it to apoptosis and stress response pathways. FIR antibodies enable researchers to investigate its expression patterns, subcellular localization, and protein-protein interactions through techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Recent studies explore FIR's dual roles in tumor suppression and progression, as well as its potential implications in neurodegenerative disorders. These antibodies are pivotal for unraveling FIR's context-dependent mechanisms in development, disease, and therapeutic targeting.