| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein aristaless-like 3; Proline-rich transcription factor ALX3; ALX3; |
| Entrez GeneID | 257; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human ALX3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ALX3抗体的3篇参考文献示例(内容为模拟概括，仅供参考)：
1. **文献名称**：*ALX3在神经母细胞瘤中的表达及其临床意义*
**作者**：Smith J, et al.
**摘要**：本研究通过ALX3特异性抗体进行免疫组化分析，发现ALX3蛋白在神经母细胞瘤中高表达，且与患者不良预后显著相关，提示其作为潜在生物标志物的价值。
2. **文献名称**：*ALX3基因敲除小鼠模型的面部发育缺陷研究*
**作者**：Zhang L, et al.
**摘要**：利用ALX3抗体进行Western blot和胚胎组织免疫荧光，证实ALX3在小鼠颅面发育中关键作用，敲除后导致严重面部骨骼畸形，揭示其在神经嵴细胞分化中的调控机制。
3. **文献名称**：*ALX3在结直肠癌中的表观遗传沉默及其功能*
**作者**：Wang H, et al.
**摘要**：通过ALX3抗体检测结直肠癌组织及细胞系，发现ALX3表达受DNA甲基化抑制，恢复其表达可抑制肿瘤细胞增殖，表明ALX3具有抑癌基因特性。
4. **文献名称**：*ALX3抗体在胚胎干细胞分化中的应用*
**作者**：Garcia R, et al.
**摘要**：开发了一种高特异性ALX3多克隆抗体，用于追踪胚胎干细胞向中胚层分化过程中的蛋白动态变化，为研究早期发育提供工具。
(注：以上文献为示例性内容，实际引用请通过PubMed或学术数据库检索核实。)
The ALX3 antibody is designed to target the ALX3 protein, a member of the Aristaless-related homeobox (ALX) transcription factor family. ALX3. encoded by the *ALX3* gene, plays critical roles in embryonic development, particularly in craniofacial morphogenesis and neural crest cell differentiation. It contains a conserved homeodomain that facilitates DNA binding, enabling regulation of genes involved in cell proliferation, differentiation, and tissue patterning. Dysregulation of ALX3 has been implicated in congenital defects, such as frontonasal dysplasia, and certain cancers, where it may act as either an oncogene or tumor suppressor depending on context.
In research, ALX3 antibodies are primarily used to study protein expression, localization, and function in developmental biology and disease models. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of ALX3's role in tissue-specific gene networks. Clinically, ALX3 expression has been investigated as a potential biomarker in cancers like neuroblastoma and gastric adenocarcinoma, though its diagnostic or prognostic utility remains under evaluation. Challenges in antibody development include ensuring specificity due to homology among ALX family members. Recent studies also explore ALX3's interaction with signaling pathways like Wnt and BMP, highlighting its broader regulatory impact. Continued research aims to clarify its mechanistic contributions to development and pathology.
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