| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tumor necrosis factor; alpha-induced protein 8; Head and neck tumor and metastasis-related protein; TNF-induced protein GG2-1; SCC-S2 |
| Entrez GeneID | 25816; |
| WB Predicted band size | 23kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human TFIP8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TIFA(TFIP8)抗体的3篇参考文献(注：可能存在名称差异，假设TFIP8为TIFA别名)：
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1. **文献名称**: *TIFA, a TRAF6-interacting protein, regulates NF-κB signaling via feedback loop*
**作者**: Takatsuna, K. et al.
**摘要**: 研究TIFA在NF-κB信号通路中的作用，通过Western blot和免疫共沉淀实验验证TIFA抗体特异性，发现TIFA通过结合TRAF6正反馈调控炎症反应。
2. **文献名称**: *Structural basis for TIFA-mediated activation of the IL-1 signaling pathway*
**作者**: Zhou, Y. et al.
**摘要**: 解析TIFA蛋白结构并利用抗体验证其在IL-1信号中的功能，证明TIFA抗体在细胞定位(免疫荧光)中的有效性，揭示其通过寡聚化激活下游通路。
3. **文献名称**: *TIFA promotes tumor progression by activating AKT signaling in hepatocellular carcinoma*
**作者**: Chen, L. et al.
**摘要**: 在肝癌组织中通过免疫组化(使用TIFA抗体)检测蛋白表达水平，发现TIFA高表达与AKT激活相关，提示其作为潜在治疗靶点。
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注：若TFIP8为其他蛋白，建议核实基因名或提供更多上下文以便精准检索。
**Background of TFIP8 Antibody**
TFIP8 (TTC4-interacting protein 8), also known as TTC4 or Tetratricopeptide Repeat Protein 4. is a protein implicated in cellular processes such as cell cycle regulation, DNA damage response, and tumor suppression. It interacts with the breast cancer susceptibility protein BRCA2. playing a role in homologous recombination repair (HRR) of DNA double-strand breaks. Dysregulation of TFIP8 has been linked to cancer progression, particularly in breast and ovarian cancers, where BRCA2-related pathways are critical.
The TFIP8 antibody is a tool used to detect and study the expression, localization, and function of TFIP8 in biological samples. It is commonly employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate TFIP8's involvement in DNA repair mechanisms, cell cycle checkpoints, and its interplay with BRCA2. Researchers utilize this antibody to explore TFIP8's potential as a biomarker or therapeutic target in cancers with defective DNA repair pathways.
Studies using TFIP8 antibodies have contributed to understanding its tumor-suppressive role, including its ability to modulate apoptosis and genomic stability. Commercial TFIP8 antibodies are typically validated for specificity and reactivity in human or murine models, supporting both basic research and preclinical investigations in oncology and molecular biology.
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