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Rabbit Polyclonal TPH2(Ab-19) Antibody

  • 中文名: TPH2 (Ab-19)抗体
  • 别    名: Neuronal tryptophan hydroxylase; NTPH; Tryptophan 5- monooxygenase 2;
货号: IPDX41775
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNeuronal tryptophan hydroxylase; NTPH; Tryptophan 5- monooxygenase 2;
Entrez GeneID121278;
WB Predicted band size56kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized non-phosphopeptide derived from human TPH2 around the phosphorylation site of serine 19 (G-FI-S(p)-L-D).
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TPH2 (Ab-19)抗体的3篇示例参考文献(注:以下文献为假设性示例,实际文献需通过PubMed、Google Scholar等平台查询):

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1. **文献名称**: *Characterization of TPH2 (Ab-19) Antibody Specificity in Rodent Brain Tissue*

**作者**: Smith JL, et al.

**摘要**: 本研究验证了TPH2 (Ab-19)抗体在小鼠和大鼠脑组织中的特异性,通过免疫印迹和免疫组化实验证明其选择性识别TPH2蛋白(分子量约55 kDa),并与TPH1无交叉反应。结果显示该抗体适用于检测中缝核区域的TPH2表达。

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2. **文献名称**: *TPH2 Expression in Depression: Insights from Ab-19 Immunoreactivity*

**作者**: Chen R, et al.

**摘要**: 利用TPH2 (Ab-19)抗体分析抑郁症患者尸脑样本,发现前额叶皮层和中缝核的TPH2蛋白水平显著降低,提示5-羟色胺合成异常可能与抑郁病理相关。研究强调了该抗体在人类组织中的可靠性。

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3. **文献名称**: *Comparative Analysis of TPH2 Antibodies in Neurodegenerative Models*

**作者**: Gonzalez M, et al.

**摘要**: 比较多种TPH2抗体(包括Ab-19)在阿尔茨海默病模型中的应用,发现Ab-19在免疫荧光中呈现高信噪比,能清晰标记转基因小鼠脑干的TPH2阳性神经元,支持其在神经退行性研究中的适用性。

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**提示**:实际文献需通过关键词“TPH2 antibody Ab-19”或“TPH2 (Ab-19) validation”在学术数据库中检索,并关注抗体验证、神经精神疾病或分子机制相关研究。

背景信息

The TPH2 (Ab-19) antibody is a selective immunological tool designed to detect tryptophan hydroxylase 2 (TPH2), a rate-limiting enzyme in serotonin biosynthesis within the central nervous system. TPH2 catalyzes the conversion of tryptophan to 5-hydroxytryptophan (5-HTP), a precursor to serotonin (5-HT), and is primarily expressed in serotonergic neurons of the brainstem. Unlike TPH1. its peripheral counterpart, TPH2 is critical for maintaining central serotonin levels, which regulate mood, cognition, and neuropsychiatric functions. The Ab-19 clone specifically targets a unique epitope on the TPH2 protein, enabling differentiation from TPH1 in assays. This antibody is widely used in neuroscience research to study serotonin-related disorders, such as depression, anxiety, and schizophrenia. It is validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, often in models like rodent brain tissues or cell lines expressing TPH2. Researchers also employ it to explore TPH2 expression changes under pathological conditions or pharmacological interventions. Its specificity and reliability make it a key reagent for mapping serotonergic pathways and understanding the molecular basis of neuropsychiatric diseases. Proper controls, including TPH2 knockout models, are recommended to confirm signal authenticity.

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