Rabbit Polyclonal HDAC7A(Ab-155) Antibody

The HDAC7A (Ab-155) antibody is a specific immunological tool designed to target histone deacetylase 7A (HDAC7), a member of the class IIa HDAC family. HDAC7A plays a critical role in epigenetic regulation by catalyzing the removal of acetyl groups from lysine residues on histones, leading to chromatin condensation and transcriptional repression. It is involved in diverse cellular processes, including cell differentiation, apoptosis, and immune regulation. Unlike other HDACs, class IIa members like HDAC7A exhibit tissue-specific expression and shuttle between the nucleus and cytoplasm, with their activity often modulated by post-translational modifications such as phosphorylation. The Ab-155 epitope corresponds to a region surrounding the serine 155 residue (Ser155), a site linked to regulatory signaling pathways. This antibody is commonly used in applications like Western blotting, immunoprecipitation, and immunofluorescence to study HDAC7A expression, localization, and function in various contexts, such as cancer, cardiovascular diseases, and immune disorders. Its specificity for HDAC7A, validated through knockout or knockdown controls, ensures minimal cross-reactivity with other HDAC isoforms. Researchers leverage this antibody to explore HDAC7A’s role in gene silencing, its interaction with transcription factors (e.g., MEF2), and its potential as a therapeutic target in diseases driven by epigenetic dysregulation.