Rabbit Polyclonal FRS2(Ab-196) Antibody

The FRS2 (Ab-196) antibody is a monoclonal antibody specifically designed to recognize fibroblast growth factor receptor substrate 2 (FRS2), a key adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. FRS2. encoded by the *FRS2* gene, contains an N-terminal phosphotyrosine-binding (PTB) domain that interacts with activated FGFRs and multiple C-terminal tyrosine phosphorylation sites. These sites serve as docking platforms for downstream signaling molecules like GRB2 and SOS, facilitating activation of pathways such as MAPK/ERK and PI3K-AKT, which regulate cell proliferation, differentiation, and survival. FRS2 is critical in embryonic development, tissue repair, and metabolic regulation, with dysregulation linked to cancers and developmental disorders. The Ab-196 clone is widely used in applications like Western blotting, immunoprecipitation, and immunofluorescence to study FRS2 expression, localization, and protein interactions. Its specificity is often validated using FRS2-knockout controls, ensuring reliable detection in cellular or tissue samples. Researchers employ this antibody to investigate FGFR signaling dynamics, therapeutic responses in oncology, and FRS2's role as a potential biomarker or drug target. By enabling precise analysis of FRS2-mediated pathways, Ab-196 contributes to understanding FGFR-related diseases and developing targeted therapies.