Rabbit Polyclonal PKG2(Ab-126) Antibody

The PKG2 (Ab-126) antibody is a monoclonal antibody specifically designed to target cGMP-dependent protein kinase type II (PKG2 or PRKG2), a key enzyme in the cGMP signaling pathway. PKG2 is activated by cyclic guanosine monophosphate (cGMP) and plays critical roles in regulating physiological processes such as smooth muscle relaxation, platelet aggregation, and neuronal signaling. It is expressed in tissues including the brain, intestine, and kidneys. The Ab-126 antibody, often generated in mice or rabbits, recognizes the C-terminal region of human PKG2. enabling the detection of endogenous PKG2 in assays like Western blotting, immunohistochemistry, and immunofluorescence. Its high specificity minimizes cross-reactivity with other kinase family members, particularly PKG1 (PRKG1), making it valuable for distinguishing between the two isoforms. Research utilizing this antibody has advanced understanding of PKG2's involvement in diseases such as colorectal cancer, where PKG2 dysregulation impacts cell proliferation and apoptosis. It is also used to study PKG2's role in gastrointestinal motility disorders and cardiovascular pathologies. As a tool, Ab-126 supports mechanistic studies of cGMP-mediated signaling, drug development targeting PKG pathways, and validation of PKG2 expression in experimental models.