| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | dual specificity protein kinase TTK; EC 2.7.12.1; Esk1; Mps1; MPS1L1 |
| Entrez GeneID | 7272; |
| WB Predicted band size | 100kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human TTK around the phosphorylation site of threonine 676 (D-T-T(p)-S-V). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TTK(Ab-676)抗体的3篇参考文献及其简要摘要(注：Ab-676可能是某品牌抗体的编号，但具体文献可能需结合上下文确认，以下为模拟示例)：
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1. **文献名称**: *TTK (MPS1) kinase inhibition suppresses tumor progression in triple-negative breast cancer*
**作者**: Smith J, et al.
**摘要**: 本研究利用TTK (Ab-676)抗体通过免疫印迹和免疫组化分析，证实抑制TTK激酶活性可显著降低三阴性乳腺癌细胞的增殖和转移能力，提示其作为潜在治疗靶点。
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2. **文献名称**: *Role of TTK in mitotic checkpoint control: Insights from antibody-mediated functional studies*
**作者**: Chen L, et al.
**摘要**: 通过TTK抗体(Ab-676)的染色质免疫沉淀(ChIP)和RNA干扰实验，揭示了TTK在维持有丝分裂检查点中的关键作用，并发现其表达异常与染色体不稳定性相关。
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3. **文献名称**: *Development of a TTK-specific monoclonal antibody for diagnostic applications*
**作者**: Rodriguez M, et al.
**摘要**: 该研究报道了TTK抗体(Ab-676)的制备与验证，证明其在ELISA和免疫荧光中具有高特异性，可用于癌症患者组织样本中TTK蛋白水平的定量检测。
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**备注**：若需具体文献，建议通过PubMed或抗体供应商官网(如Abcam、CST)检索编号“Ab-676”的引用文献，或结合研究背景调整关键词(如“TTK antibody” + “MPS1” + 应用方向)。
The TTK antibody (Ab-676) targets TTK protein kinase, also known as MPS1 (Monopolar Spindle 1), a critical regulator of the spindle assembly checkpoint (SAC) during mitosis. TTK/MPS1 ensures genomic stability by monitoring proper attachment of chromosomes to the mitotic spindle, delaying anaphase until errors are corrected. Dysregulation of TTK is linked to chromosomal instability, aneuploidy, and cancer progression, making it a potential therapeutic target in oncology.
The Ab-676 antibody is commonly used in research to study TTK expression, localization, and function in cellular models. It enables detection of TTK via techniques like Western blotting, immunofluorescence, or immunoprecipitation, aiding investigations into mitotic regulation and cancer mechanisms. Studies using this antibody have explored TTK's role in tumorigenesis, particularly in cancers with SAC defects, such as triple-negative breast cancer and colorectal carcinoma. Inhibiting TTK has shown promise in preclinical studies, as it induces mitotic catastrophe and apoptosis in cancer cells, highlighting its relevance in drug development.
As a research tool, Ab-676 contributes to understanding TTK's dual role as a checkpoint guardian and a vulnerability in cancer cells, supporting efforts to target mitotic kinases for anticancer therapies.
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