Rabbit Polyclonal MAP3K7(Ab-187) Antibody

The MAP3K7 (Ab-187) antibody is a widely used tool in molecular biology research for detecting mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TGF-β-activated kinase 1 (TAK1). MAP3K7 is a serine/threonine kinase critical in regulating diverse signaling pathways, including NF-κB, JNK, and p38 MAPK cascades, which are involved in immune responses, apoptosis, and stress responses. The Ab-187 epitope corresponds to a phosphorylated threonine residue at position 187 (Thr187) within the activation loop of human MAP3K7. a site essential for its kinase activity. This phosphorylation event is induced by upstream signals, such as cytokines (e.g., TGF-β, IL-1) or Toll-like receptor ligands, enabling MAP3K7 to activate downstream effectors. The antibody is commonly employed in Western blotting, immunoprecipitation, and functional studies to assess MAP3K7 activation status in cell lines, tissues, or disease models. Its specificity for the phosphorylated form allows researchers to distinguish active MAP3K7 from its inactive state, aiding investigations into signaling dynamics in cancer, inflammation, and neurodegenerative disorders. Validated in multiple species (human, mouse, rat), MAP3K7 (Ab-187) is a key reagent for elucidating mechanisms underlying cellular stress responses and therapeutic targeting of MAP3K7-associated pathways.