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Rabbit Polyclonal ICK(Ab-159) Antibody

  • 中文名： ICK (Ab-159)抗体
  • 别    名： EC 2.7.11.22; hICK; ICK; Intestinal cell kinase; KIAA0936
货号: IPDX41708
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesEC 2.7.11.22; hICK; ICK; Intestinal cell kinase; KIAA0936
Entrez GeneID22858;
WB Predicted band size65kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized non-phosphopeptide derived from human ICK around the phosphorylation site of tyrosine 159 (T-D-Y(p)-V-S).
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是模拟生成的3篇关于ICK (Ab-159)抗体的参考文献示例(注：实际文献需通过学术数据库检索确认)：

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1. **文献名称**: "ICK Kinase Regulates Cell Cycle Progression Through Phosphorylation of Cyclin-Dependent Kinase Inhibitors"

**作者**: Zhang, Y. et al.

**摘要**: 本研究利用ICK (Ab-159)抗体进行免疫沉淀和Western blot分析，发现ICK通过磷酸化p27Kip1调控G1/S期转换，揭示其在细胞周期检查点中的关键作用。

2. **文献名称**: "Ab-159 Antibody-Based Detection of ICK in Colorectal Cancer Tissues Predicts Poor Prognosis"

**作者**: Tanaka, H. et al.

**摘要**: 通过免疫组化(使用Ab-159抗体)分析结直肠癌样本，发现ICK高表达与患者生存率下降显著相关，提示其作为潜在生物标志物的价值。

3. **文献名称**: "ICK Localization to Primary Cilia Requires Ab-159-Specific Epitope Recognition"

**作者**: Johnson, R.L. et al.

**摘要**: 本研究通过Ab-159抗体的免疫荧光技术，证实ICK在纤毛基部的特异性定位，并发现其缺失导致纤毛发生缺陷，影响Hedgehog信号通路。

4. **文献名称**: "Structural Insights into ICK Kinase Activation Using Ab-159 for Conformational Studies"

**作者**: Müller, S. et al.

**摘要**: 结合Ab-159抗体的表位结合特性，利用冷冻电镜解析ICK激酶活化构象，揭示其自抑制结构域的调控机制。

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建议通过PubMed、Web of Science或Google Scholar以关键词 "ICK antibody Ab-159" 或 "Intestinal Cell Kinase Ab-159" 检索真实文献。

背景信息

The ICK (Ab-159) antibody is a monoclonal antibody designed to specifically target and detect Intestinal Cell Kinase (ICK), a serine/threonine protein kinase encoded by the *ICK* gene. ICK is part of the MAPK/MAK/MRK protein kinase superfamily and plays critical roles in regulating ciliogenesis, cell cycle progression, and embryonic development. It is involved in signaling pathways that influence cellular responses to environmental cues, including Hedgehog (Hh) signaling, which is essential for tissue patterning and stem cell regulation. Dysregulation of ICK has been linked to developmental disorders, such as ciliopathies (e.g., Joubert syndrome), and certain cancers due to its impact on cell proliferation and differentiation. The Ab-159 antibody is commonly used in research applications like Western blotting, immunohistochemistry, and immunofluorescence to study ICK's expression, localization, and interaction partners. Its validation in knockout cell lines or tissues ensures specificity, making it a reliable tool for investigating ICK's functional mechanisms in both normal physiology and disease contexts. Researchers utilize this antibody to explore ICK's role in cellular stress responses, metabolic regulation, and potential therapeutic targeting in pathological conditions.

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