关键信息
-
基因名
KLRB1
- 应用
-
别名
KLRB1;CLEC5B;NKRP1A;Killer cell lectin-like receptor subfamily B member 1
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q12918
-
表达区间
67-225aa
-
氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMQKSSIE KCSVDIQQSR NKTTERPGLL NCPIYWQQLR EKCLLFSHTV NPWNNSLADC STKESSLLLI RDKDELIHTQ NLIRDKAILF WIGLNFSLSE KNWKWINGSF LNSNDLEIRG DAKENSCISI SQTSVYSEYC STEIRWICQK ELTPVRNKVY PDS
-
分子量
21 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
KLRB1, or Killer Cell Lectin-Like Receptor B1, is a key receptor predominantly expressed on natural killer (NK) cells and certain subsets of T cells. It plays a crucial role in the immune response by recognizing and binding to specific ligands on target cells, ultimately influencing the activation, inhibition, and cytotoxic functions of these immune cells. Research into KLRB1 is of significant interest due to its potential implications in cancer immunotherapy, infectious disease responses, and autoimmune disorders. The receptor's ability to modulate NK cell activity provides insights into developing strategies that enhance or inhibit immune responses, offering prospects for therapeutic interventions. Recombinant KLRB1 proteins have been utilized to study its structural and functional properties, enabling a deeper understanding of its interactions with ligands and downstream signaling pathways. By investigating the implications of KLRB1 in immune regulation, researchers aim to uncover novel targets for therapeutic applications and improve the efficacy of existing immunotherapies. Overall, the study of KLRB1 recombinant proteins represents a promising avenue for advancing our understanding of immune modulation and enhancing treatment strategies for various diseases.
