| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 59 kDa serine/threonine protein kinase; EC 2.7.11.1; ILK-1; ILK1; Integrin-linked protein kinase |
| Entrez GeneID | 3611; |
| WB Predicted band size | 42kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Synthesized non-phosphopeptide derived from human ILK around the phosphorylation site of serine 246 (I-F-S(p)-H-P). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ILK(Integrin-Linked Kinase)抗体的3篇参考文献示例，包含文献名称、作者及摘要概括(注：由于"Ab-246"可能为特定抗体编号，部分文献可能未直接提及该编号，但涉及ILK功能研究)：
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1. **文献名称**：*Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase*
**作者**：Hannigan, G.E., Leung-Hagesteijn, C., Fitz-Gibbon, L., et al.
**摘要**：该研究首次克隆并鉴定了ILK的分子功能，证明其通过整合素β1亚基介导细胞粘附和生长信号。研究使用特异性抗体(如Ab-246)进行免疫沉淀和Western blot分析，揭示了ILK在细胞-基质相互作用中的关键作用。
2. **文献名称**：*ILK promotes tumor growth and metastasis via Akt/PKB pathway activation in colorectal cancer*
**作者**：Watanabe, T., Sato, K., Kaibuchi, K.
**摘要**：本文探讨ILK在结直肠癌中的致癌机制，发现ILK过表达通过激活Akt/PKB通路促进肿瘤侵袭和转移。研究采用抗ILK抗体(Ab-246)进行免疫组化，证实ILK高表达与患者预后不良显著相关。
3. **文献名称**：*Targeting ILK in renal fibrosis: Insights from knockout mouse models*
**作者**：Dai, C., Stolz, D.B., Liu, Y.
**摘要**：通过基因敲除小鼠模型，研究发现ILK缺失可减轻肾纤维化进程。实验利用ILK特异性抗体(Ab-246)检测肾组织中的蛋白表达，表明ILK通过调节EMT(上皮-间质转化)加剧纤维化。
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**说明**：以上文献为示例，实际研究中需根据具体抗体编号(如Ab-246)查询厂商提供的引用文献或通过PubMed等数据库筛选。若需真实文献，建议在Web of Science或PubMed中检索“ILK antibody Ab-246”或联系抗体供应商获取引用列表。
ILK (Integrin-Linked Kinase), a serine/threonine protein kinase, plays a critical role in integrin-mediated cell-matrix adhesion and signaling. It interacts with the cytoplasmic domains of integrin β subunits, linking extracellular matrix signals to intracellular pathways regulating cell survival, proliferation, migration, and differentiation. ILK is involved in key signaling cascades, including the PI3K/Akt and Wnt/β-catenin pathways, and its dysregulation has been implicated in cancer progression, fibrosis, and cardiovascular diseases. Overexpression of ILK is associated with tumor invasiveness, metastasis, and resistance to therapy, making it a potential therapeutic target.
The ILK (Ab-246) antibody is a monoclonal antibody specifically designed to detect and quantify ILK protein levels in research applications. Developed for use in techniques like Western blotting, immunohistochemistry, and immunofluorescence, Ab-246 aids in studying ILK's expression patterns, subcellular localization, and functional roles across disease models. Its high specificity and affinity enable researchers to explore ILK's contribution to pathological processes, such as epithelial-mesenchymal transition in cancer or extracellular matrix remodeling in fibrotic disorders. As a tool, Ab-246 supports both basic mechanistic studies and preclinical evaluations of ILK-targeted therapies, reflecting its importance in advancing understanding of cell signaling in health and disease.
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