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Rabbit Polyclonal EPHB1/2/3/4(Ab-600/602/614/596) Antibody

  • 中文名： EPHB1/2/3/4 (Ab-600/602/614/596)抗体
  • 别    名： EC 2.7.10.1; ELK; EPB1; Eph receptor B1; Ephrin type-B receptor 1 precursor
货号: IPDX41707
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesEC 2.7.10.1; ELK; EPB1; Eph receptor B1; Ephrin type-B receptor 1 precursor
Entrez GeneID2047;
WB Predicted band size118kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized non-phosphopeptide derived from human EPHB1/2/3/4 around the phosphorylation site of tyrosine 600/602/614/596 (F-T-Y(p)-E-D).
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3-4条关于EPHB1/2/3/4(针对磷酸化位点Y600/Y602/Y614/Y596)抗体的虚构参考文献示例(基于常见研究场景，非真实文献)：

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1. **"EPHB1-Y600 phosphorylation mediates tumor cell invasion via RhoA activation"**

*Authors: Lee S, et al. (2023)*

摘要：该研究使用抗EPHB1 (Phospho-Y600) 抗体发现，EPHB1在Y600位点的磷酸化通过激活RhoA信号通路促进乳腺癌细胞侵袭，提示其作为转移性癌症的潜在治疗靶点。

2. **"EPHB2-Y602-dependent axon guidance requires ligand-receptor clustering"**

*Authors: Martinez D, et al. (2021)*

摘要：通过特异性抗EPHB2 (Phospho-Y602) 抗体检测，揭示神经元轴突导向过程中EPHB2在Y602位点的自磷酸化依赖配体-受体簇的形成，为神经再生研究提供新机制。

3. **"Phosphorylated EPHB3-Y614 regulates angiogenesis in colorectal cancer"**

*Authors: Wang H, et al. (2020)*

摘要：利用抗EPHB3 (Phospho-Y614) 抗体证实，Y614位点的磷酸化通过调控VEGF旁分泌信号增强结直肠癌血管生成，为抗血管治疗提供新方向。

4. **"EPHB4-Y596 phosphorylation promotes resistance to EGFR inhibitors in lung cancer"**

*Authors: Gupta R, et al. (2019)*

摘要：通过抗EPHB4 (Phospho-Y596) 抗体分析发现，Y596磷酸化激活下游STAT3通路，导致肺癌对EGFR靶向药物耐药，提示联合靶向治疗策略。

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注：以上文献为模拟示例，实际引用需以真实发表的论文为准。建议通过PubMed或Web of Science检索具体抗体货号(如Abcam# ab12345)关联的文献。

背景信息

The EPHB1/2/3/4 antibodies (Ab-600/602/614/596) target members of the Ephrin (EPH) receptor tyrosine kinase family, which play critical roles in cell-cell communication, tissue patterning, and developmental processes. EPH receptors are divided into A (EPHA) and B (EPHB) subclasses based on ligand specificity and sequence homology. EPHB1 (Ab-600), EPHB2 (Ab-602), EPHB3 (Ab-614), and EPHB4 (Ab-596) are transmembrane receptors that bind membrane-anchored ephrin-B ligands, triggering bidirectional signaling pathways regulating cell adhesion, migration, and boundary formation. These antibodies are commonly used in neuroscience, cancer, and vascular biology research. For example, EPHB2 is implicated in synaptic plasticity and axon guidance, while EPHB4 is critical for vascular development and angiogenesis. The antibodies are typically validated in applications like Western blotting, immunohistochemistry, or immunofluorescence, often with knockout (KO) controls to confirm specificity. Aberrant EPHB signaling is linked to tumor progression, metastasis, and neurological disorders, making these antibodies valuable tools for studying receptor-ligand interactions, downstream signaling mechanisms (e.g., MAPK/ERK pathways), and therapeutic targeting. Host species (e.g., rabbit or mouse) and epitope details (phosphorylation sites, extracellular/cytoplasmic domains) vary by product, requiring careful selection based on experimental needs.

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