| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1:1000-1:5000 | Human,Mouse,Rat |
| Aliases | integrin beta 3 binding protein (beta3-endonexin), CENPR, NRIF3, TAP20, CENP-R, HSU37139 |
| Entrez GeneID | 23421; |
| WB Predicted band size | 15kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4篇关于ITGB3BP抗体的模拟参考文献(虚构内容，仅供参考)：
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1. **文献名称**: *ITGB3BP as a Prognostic Biomarker in Breast Cancer: Immunohistochemical Analysis*
**作者**: Smith A, et al.
**摘要**: 本研究通过免疫组化技术检测了乳腺癌组织中ITGB3BP的表达水平，发现其过表达与患者不良预后显著相关。ITGB3BP抗体(克隆号#5C2)被用于组织切片染色，证实了ITGB3BP通过调控整合素信号通路促进肿瘤侵袭。
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2. **文献名称**: *Interaction of ITGB3BP with β3 Integrin in Platelet Activation*
**作者**: Zhang L, et al.
**摘要**: 利用ITGB3BP特异性抗体(货号ab123)进行Western blot和免疫共沉淀实验，揭示了ITGB3BP与整合素β3亚基的直接相互作用，并证明其在血小板活化和血栓形成中起关键作用。
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3. **文献名称**: *ITGB3BP Antibody-Based Detection in Colorectal Cancer Serum*
**作者**: Tanaka K, et al.
**摘要**: 开发了一种基于ITGB3BP抗体的ELISA检测方法，用于定量结直肠癌患者血清中的ITGB3BP水平。结果显示，血清ITGB3BP浓度升高与肿瘤转移和化疗耐药性显著相关。
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4. **文献名称**: *Targeting ITGB3BP in NF-κB Signaling: A Therapeutic Approach*
**作者**: Müller R, et al.
**摘要**: 通过ITGB3BP中和抗体(品系mAb-IT3)阻断实验，证明ITGB3BP通过激活NF-κB通路促进炎症因子释放。该抗体在类风湿性关节炎小鼠模型中显著减轻了关节炎症。
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**注**：以上文献为模拟生成，实际研究中请通过PubMed、Google Scholar等平台检索真实文献(关键词：ITGB3BP antibody, TAPAN1. integrin signaling)。
The ITGB3BP (Integrin Beta 3 Binding Protein), also known as CENP-R, is a multifunctional protein involved in cell adhesion, signaling, and chromosomal organization. It interacts with integrin β3 subunits, which are critical for cell-matrix adhesion and signaling in processes like platelet aggregation, angiogenesis, and cancer metastasis. ITGB3BP's role extends to the nucleus, where it participates in centromere assembly and chromosome segregation during mitosis, linking cell adhesion pathways to genomic stability.
Antibodies targeting ITGB3BP are essential tools for studying its expression, localization, and interactions. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to explore its dual roles in cytoplasmic signaling and nuclear functions. In research, ITGB3BP antibodies help elucidate mechanisms in cancer biology, particularly in tumor progression and metastasis, where dysregulated integrin signaling is common. They also aid in studying genetic disorders related to chromosomal instability, such as certain congenital syndromes.
Commercial ITGB3BP antibodies are typically validated for specificity across human, mouse, and rat models, with applications in both basic research and clinical diagnostics. Understanding ITGB3BP's functions through antibody-based assays contributes to potential therapeutic strategies targeting integrin pathways or mitotic errors in diseases.
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