| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1:2000-1:5000 | Human,Mouse,Rat |
| Aliases | ATP-binding cassette sub-family B member 8, MABC1, M-ABC1, EST328128 |
| Entrez GeneID | 11194; |
| WB Predicted band size | 76kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to a region derived from 394-693 amino acids of Human ATP-binding cassette sub-family B member 8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ABCB8抗体的3篇代表性文献的简要信息(注：以下内容基于模拟数据，实际文献需通过学术数据库检索)：
1. **文献名称**：*ABCB8 regulates mitochondrial iron-sulfur cluster biogenesis and its antibody-based detection in murine tissues*
**作者**：Smith JL, et al.
**摘要**：本研究利用特异性ABCB8抗体，通过免疫印迹和免疫组化技术，揭示了ABCB8蛋白在小鼠心脏和肝脏中的高表达，并证实其在线粒体铁硫簇转运中的关键作用。
2. **文献名称**：*ABCB8 antibody validation for functional studies in drug-resistant cancer cell lines*
**作者**：Chen R, et al.
**摘要**：文章验证了商业化ABCB8抗体的特异性，并发现ABCB8在化疗耐药的卵巢癌细胞中表达上调，提示其可能通过调控线粒体药物外排参与肿瘤耐药机制。
3. **文献名称**：*ABCB8 deficiency detected by immunohistochemistry links to mitochondrial dysfunction in diabetic cardiomyopathy*
**作者**：Wang Y, et al.
**摘要**：通过抗体标记技术，研究发现糖尿病模型小鼠心肌组织中ABCB8蛋白表达显著降低，且与线粒体功能受损相关，表明ABCB8可能成为代谢性心脏病的潜在治疗靶点。
如需实际文献，建议在PubMed或Google Scholar中搜索关键词“ABCB8 antibody”或“ABCB8 function”。
The ABCB8 antibody is a research tool designed to target the ATP-binding cassette subfamily B member 8 (ABCB8), a mitochondrial transmembrane protein involved in cellular transport processes. ABCB8. part of the ATP-binding cassette (ABC) transporter superfamily, plays a critical role in mitochondrial iron homeostasis, oxidative stress regulation, and the export of peptides or metabolites. It is highly expressed in tissues with high metabolic demands, such as the heart, skeletal muscle, and liver. Dysregulation of ABCB8 has been implicated in cardiovascular diseases, mitochondrial disorders, and cancer chemoresistance, making it a subject of interest in both basic and clinical research.
ABCB8 antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression, localization, and quantification in cellular or tissue samples. These antibodies aid in studying ABCB8's interaction with mitochondrial pathways, its role in ferroptosis, and its potential as a biomarker or therapeutic target. Commercially available ABCB8 antibodies vary in host species (e.g., rabbit, mouse), clonality (monoclonal/polyclonal), and epitope specificity, requiring validation for experimental reproducibility. Recent studies highlight its association with doxorubicin resistance in cancer and its protective effects against ischemia-reperfusion injury, underscoring its multifaceted biological significance.
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