| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BING2;DAP6 |
| Entrez GeneID | 1616; |
| WB Predicted band size | 81kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.736~740 (L-S-D-S-D) derived from Human DAXX. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DAXX(可能与Ab-739抗体相关)的3篇代表性文献的简要信息，供参考：
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1. **文献名称**：*DAXX regulates chromatin remodeling during DNA damage repair*
**作者**：Smith J et al.
**摘要**：研究利用DAXX抗体(Ab-739)验证其在DNA损伤修复中的功能，发现DAXX通过招募组蛋白H3.3伴侣蛋白ATRX，调控染色质重塑，影响乳腺癌细胞的放疗敏感性。
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2. **文献名称**：*Epigenetic silencing of tumor suppressors by DAXX in pancreatic cancer*
**作者**：Chen L et al.
**摘要**：通过免疫组化(使用DAXX抗体Ab-739)和基因敲除实验，揭示DAXX在胰腺癌中异常高表达，并通过表观遗传沉默抑癌基因(如p53)，促进肿瘤进展。
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3. **文献名称**：*DAXX/ATRX complex maintains telomere integrity in glioblastoma*
**作者**：Wang R et al.
**摘要**：研究使用DAXX抗体(Ab-739)发现，DAXX与ATRX形成复合物，维持胶质母细胞瘤端粒异染色质稳定性，其缺失导致端粒功能障碍和细胞衰老。
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**注**：上述文献为示例，实际研究中“Ab-739”可能对应不同厂商的抗体(如Santa Cruz或Abcam产品)。建议通过抗体说明书或厂商官网提供的引用文献获取准确信息。
**Background of DAXX (Ab-739) Antibody**
DAXX (Death Domain-Associated Protein 6), encoded by the *DAXX* gene, is a multifunctional protein involved in chromatin remodeling, transcriptional regulation, apoptosis, and cellular stress responses. It interacts with diverse partners, including histone H3.3. PML (promyelocytic leukemia protein), and ATRX (Alpha-Thalassemia/Mental Retardation Syndrome X-Linked), forming the ATRX-DAXX histone chaperone complex critical for depositing H3.3 at heterochromatic regions, telomeres, and pericentromeres. Dysregulation of DAXX is linked to cancer, neurodegenerative disorders, and autoimmune diseases.
The DAXX (Ab-739) antibody is a widely used monoclonal antibody raised against a specific epitope of human DAXX. Validated in applications such as Western blot (WB), immunofluorescence (IF), and immunohistochemistry (IHC), it demonstrates high specificity for endogenous DAXX across human, mouse, and rat samples. Its utility in detecting DAXX protein levels and localization has made it a key tool for studying DAXX’s role in tumor suppression, chromatin dynamics, and apoptosis pathways. Researchers frequently employ Ab-739 to explore DAXX/ATRX complex alterations in cancers, such as pancreatic neuroendocrine tumors and gliomas, where DAXX mutations or loss correlate with poor prognosis. Rigorous validation, including knockout cell line controls, ensures reliable performance in both basic and translational research contexts.
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