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Rabbit Polyclonal Jak2(Ab-570) Antibody

  • 中文名: Jak2(Ab-570)抗体
  • 别    名: JAK-2; Janus kinase 2; kinase Jak2
货号: IPDX41550
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesJAK-2; Janus kinase 2; kinase Jak2
Entrez GeneID3717;
WB Predicted band size125kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenPeptide sequence around aa.568~572 (G-D-Y-G-Q) derived from Human JAK2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是为您模拟的3篇关于Jak2 (Tyr570磷酸化位点)抗体的研究文献示例(注:实际文献可能需要通过PubMed或学术数据库查询,此处为基于常见研究的假设性描述):

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1. **文献名称**: "JAK2 Tyr570 phosphorylation regulates hematopoietic stem cell self-renewal signaling"

**作者**: Thompson R, et al.

**摘要**: 本研究利用Jak2 (Tyr570)特异性抗体,通过免疫印迹和流式细胞术,揭示了Tyr570磷酸化在JAK2-STAT5通路中的关键作用。实验表明,该位点的修饰可增强造血干细胞的自我更新能力,为骨髓增殖性疾病的机制提供了新见解。

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2. **文献名称**: "Inflammatory cytokine-induced JAK2 activation requires phosphorylation at Tyr570: A study using site-specific antibodies"

**作者**: Li X, et al.

**摘要**: 作者通过Jak2 (Ab-570)抗体检测Tyr570磷酸化水平,发现IL-6等炎症因子刺激下该位点磷酸化显著上调,并通过CRISPR突变验证了其对JAK2激酶活性的调控功能,提示其在炎症性疾病中的潜在治疗靶点。

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3. **文献名称**: "Targeting JAK2 Tyr570 phosphorylation overcomes resistance to ruxolitinib in myelofibrosis models"

**作者**: Gupta S, et al.

**摘要**: 研究利用Jak2磷酸化特异性抗体(Ab-570)检测患者样本,发现Tyr570的异常激活与鲁索替尼耐药相关。体内外实验证明,联合抑制该位点可显著增强药物敏感性,为骨髓纤维化的联合治疗策略提供依据。

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如需真实文献,建议通过学术数据库(如PubMed)搜索关键词:**"JAK2 Tyr570 phosphorylation antibody"** 或具体抗体货号(如Cell Signaling Technology公司的#3771)。实际研究中抗体应用常注明公司及编号(如CST #3771对应Tyr1007/1008位点,需确认目标位点)。

背景信息

The Jak2 (Ab-570) antibody is a monoclonal or polyclonal immunoglobulin designed to specifically detect the Janus kinase 2 (Jak2) protein, a non-receptor tyrosine kinase critical for cytokine and growth factor signaling. Jak2 plays a central role in the JAK-STAT pathway, mediating cellular responses to interleukins, interferons, and hormones like erythropoietin. Its activation involves phosphorylation at key tyrosine residues (e.g., Tyr1007/1008), which triggers downstream signaling cascades regulating cell proliferation, differentiation, and immune responses. Dysregulation of Jak2. particularly the V617F mutation, is linked to myeloproliferative neoplasms (MPNs) such as polycythemia vera and essential thrombocythemia. The Ab-570 clone typically targets a specific epitope within Jak2. often near residues critical for its activation or regulatory interactions. This antibody is widely used in research applications like Western blotting, immunoprecipitation, or immunofluorescence to study Jak2 expression, activation status, or interactions in disease models, drug screening, or mechanistic studies. Validation often includes testing on Jak2-deficient cell lines or tissues to confirm specificity. Its development and optimization reflect the need for reliable tools to explore Jak2's role in hematopoiesis, inflammation, and cancer, aiding therapeutic targeting of Jak2-associated pathologies.

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